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Avoro Capital Advisors LLC

Q1 2026 · 13F-HR

Avoro Capital Advisors LLCholdings as filed

Filed 2026-05-15 · accession 0001104659-26-061754

$10.16B
Reported value
32
Positions
2026-03-31
Period end
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The Brief · Avoro Capital Advisors LLC · Q1 2026

AI · grounded in 13F

Avoro Capital Advisors LLC closed its position in Avidity Biosciences Inc, reducing exposure by $393.4M. The fund established a new position in 430 worth $300.2M and exited its holding in XBI for $256M. Other new entries include CYTK at $219.7M and DMRA at $98M.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
91307C102UTHRUNITED THERAPEUTICS CORP$1.56B15.3%2,630,000CommonSOLE
04351P101ASNDUSDASCENDIS PHARMA$1.16B11.4%5,062,500CommonSOLE
558868105MDGLMADRIGAL PHARMACEUTICALS INC$951.8M9.36%1,818,181CommonSOLE
501147102KRYSKRYSTAL BIOTECH INC$746.3M7.34%2,888,888CommonSOLE
04016X101ARGXARGENX SE$730.3M7.18%1,000,000CommonSOLE
04280A100ARWRARROWHEAD PHARMACEUTICALS INC$670.9M6.60%10,699,999CommonSOLE
501575104KYMRKYMERA THERAPEUTICS INC$622.6M6.12%7,474,747CommonSOLE
03753U106APLSUSDAPELLIS PHARMACEUTICALS INC$491.7M4.84%12,222,222CommonSOLE
152309100CNTACENTESSA PHARMACEUTICALS PLC$454.0M4.47%11,430,455CommonSOLE
15102K100CELCCELCUITY INC$385.2M3.79%3,375,000CommonSOLE
98420N105XENEXENON PHARMACEUTICALS INC$336.0M3.31%5,777,777CommonSOLE
86366E106GPCRSTRUCTURE THERAPEUTICS INC$316.0M3.11%6,555,555CommonSOLE
880881107430TERNS PHARMACEUTICALS INC$300.2M2.95%5,695,000CommonSOLE
92337R101VERAVERA THERAPEUTICS INC$236.9M2.33%5,888,888CommonSOLE
76155X100RVMDREVOLUTION MEDICINES INC$228.0M2.24%2,344,444CommonSOLE
23282W605CYTKCYTOKINETICS INC$219.7M2.16%3,333,333CommonSOLE
67576A100OCULOCULAR THERAPEUTIX INC$104.3M1.03%12,315,000CommonSOLE
36322Q206DMRADAMORA THERAPEUTICS INC$98.0M0.96%3,783,000CommonSOLE
N90064101QUREUNIQURE NV$97.4M0.96%5,959,595CommonSOLE
877619106TSHATAYSHA GENE THERAPIES INC$97.0M0.95%21,700,000CommonSOLE
24477V105DFTXDEFINIUM THERAPEUTICS INC$94.5M0.93%5,000,000CommonSOLE
834203309SLNOSOLENO THERAPEUTICS INC$77.0M0.76%2,300,000CommonSOLE
G01767105ALKSALKERMES PLC$42.4M0.42%1,200,000CommonSOLE
81734D104SEPNSEPTERNA INC$32.1M0.32%1,337,500CommonSOLE
92790C104VRDNVIRIDIAN THERAPEUTICS INC$29.3M0.29%1,500,000CommonSOLE
G3855L106GHRSGH RESEARCH PLC$25.3M0.25%1,800,000CommonSOLE
05338F306AVTXAVALO THERAPEUTICS$21.1M0.21%1,410,000CommonSOLE
52886X107LXEOLEXEO THERAPEUTICS INC$10.8M0.11%1,875,000CommonSOLE
91307C102UTHRUNITED THERAPEUTICS CORP$10.3M0.10%380,000CALLSOLE
00032Q104WHWKWHITEHAWK THERAPEUTICS INC$9.8M0.10%2,849,402CommonSOLE
56400P706MNKDMANNKIND CORP$5.4M0.05%2,200,000CommonSOLE
15102K100CELCCELCUITY INC$3.0M0.03%200,000CALLSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.