Q3 2025 · 13F-HR
Rock Springs Capital Management LPholdings as filed
Filed 2025-11-14 · accession 0001172661-25-004882
$1.71B
Reported value
93
Positions
2025-09-30
Period end
The Brief · Rock Springs Capital Management LP · Q3 2025
AI · grounded in 13F
Rock Springs Capital Management LP initiated a new position in ARGENX SE ARGX worth $105.3M. The fund also established new holdings in Eli Lilly & Co LLY for $80.4M and Rhythm Pharmaceuticals Inc RYTM for $72.4M. Other new additions include Madrigal Pharmaceuticals Inc MDGL at $63.2M and Revolution Medicines Inc RVMD at $62.4M.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 04016X101 | ARGX | ARGENX SE | $105.3M | 6.15% | 142,750 | Common | SOLE |
| 532457108 | LLY | ELI LILLY & CO | $80.4M | 4.70% | 105,400 | Common | SOLE |
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $72.4M | 4.23% | 717,102 | Common | SOLE |
| 558868105 | MDGL | MADRIGAL PHARMACEUTICALS INC | $63.2M | 3.69% | 137,746 | Common | SOLE |
| 76155X100 | RVMD | REVOLUTION MEDICINES INC | $62.4M | 3.64% | 1,335,270 | Common | SOLE |
| N5749R100 | 2GH | MERUS N V | $56.2M | 3.28% | 597,051 | Common | SOLE |
| 604749101 | MIRM | MIRUM PHARMACEUTICALS INC | $55.8M | 3.26% | 761,126 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $55.4M | 3.24% | 385,000 | Common | SOLE |
| 89422G107 | TVTX | TRAVERE THERAPEUTICS INC | $51.7M | 3.02% | 2,164,773 | Common | SOLE |
| 04351P101 | ASNDUSD | ASCENDIS PHARMA A/S | $42.6M | 2.49% | 214,500 | Common | SOLE |
| 450056106 | IRTC | IRHYTHM TECHNOLOGIES INC | $40.4M | 2.36% | 235,000 | Common | SOLE |
| 00847X104 | AGIO | AGIOS PHARMACEUTICALS INC | $38.5M | 2.25% | 958,542 | Common | SOLE |
| 90400D108 | RARE | ULTRAGENYX PHARMACEUTICAL IN | $37.5M | 2.19% | 1,246,341 | Common | SOLE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $36.7M | 2.14% | 82,000 | Common | SOLE |
| 101137107 | BSX | BOSTON SCIENTIFIC CORP | $35.2M | 2.05% | 360,250 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $34.2M | 2.00% | 851,744 | Common | SOLE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $33.9M | 1.98% | 74,250 | Common | SOLE |
| 30063P105 | EXK | EXACT SCIENCES CORP | $32.5M | 1.90% | 593,500 | Common | SOLE |
| 70975L107 | PEN | PENUMBRA INC | $30.5M | 1.78% | 120,500 | Common | SOLE |
| 00973Y108 | AKRO | AKERO THERAPEUTICS INC | $29.7M | 1.74% | 626,526 | Common | SOLE |
| 80706P103 | SRRK | SCHOLAR ROCK HLDG CORP | $29.6M | 1.73% | 794,133 | Common | SOLE |
| 98887Q104 | ZLAB | ZAI LAB LTD | $26.8M | 1.57% | 791,193 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $26.6M | 1.56% | 951,154 | Common | SOLE |
| 501575104 | KYMR | KYMERA THERAPEUTICS INC | $25.5M | 1.49% | 450,374 | Common | SOLE |
| 88033G407 | THC | TENET HEALTHCARE CORP | $25.4M | 1.48% | 125,000 | Common | SOLE |
| 30050B101 | EVH | EVOLENT HEALTH INC | $25.0M | 1.46% | 2,950,000 | Common | SOLE |
| 142152107 | CAI | CARIS LIFE SCIENCES INC | $24.0M | 1.40% | 793,651 | Common | SOLE |
| 171757206 | CDTX | CIDARA THERAPEUTICS INC | $23.9M | 1.40% | 249,402 | Common | SOLE |
| 252131107 | DXCM | DEXCOM INC | $21.3M | 1.25% | 316,900 | Common | SOLE |
| 68170A108 | OMDA | OMADA HEALTH INC | $20.3M | 1.19% | 919,950 | Common | SOLE |
| 15117B202 | CLDX | CELLDEX THERAPEUTICS INC NEW | $18.7M | 1.09% | 721,538 | Common | SOLE |
| 92337R101 | VERA | VERA THERAPEUTICS INC | $17.9M | 1.05% | 617,396 | Common | SOLE |
| 71944F106 | PHR | PHREESIA INC | $17.6M | 1.03% | 749,116 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $17.1M | 1.00% | 288,344 | Common | SOLE |
| N62509109 | NAMS | NEWAMSTERDAM PHARMA COMPANY | $16.9M | 0.99% | 595,929 | Common | SOLE |
| 20454B104 | CMPX | COMPASS THERAPEUTICS INC | $15.7M | 0.92% | 4,474,702 | Common | SOLE |
| N69605108 | PHVS | PHARVARIS N V | $15.6M | 0.91% | 623,402 | Common | SOLE |
| 114340102 | AZTA | AZENTA INC | $15.5M | 0.91% | 540,400 | Common | SOLE |
| 603170101 | MLYS | MINERALYS THERAPEUTICS INC | $15.5M | 0.90% | 408,313 | Common | SOLE |
| 03152W109 | AM6 | AMICUS THERAPEUTICS INC | $15.3M | 0.90% | 1,947,374 | Common | SOLE |
| 78464A870 | XBI | SPDR SERIES TRUST | $15.2M | 0.89% | 151,750 | Common | SOLE |
| 03940C100 | ACLXGBX | ARCELLX INC | $14.7M | 0.86% | 178,982 | Common | SOLE |
| 86627T108 | SMMT | SUMMIT THERAPEUTICS INC | $14.7M | 0.86% | 710,000 | Common | SOLE |
| 19240Q201 | COGT | COGENT BIOSCIENCES INC | $14.5M | 0.85% | 1,008,308 | Common | SOLE |
| 29337E102 | ELVN | ENLIVEN THERAPEUTICS INC | $14.0M | 0.82% | 686,107 | Common | SOLE |
| 98937L105 | ZBIO | ZENAS BIOPHARMA INC | $12.9M | 0.75% | 580,677 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $12.6M | 0.74% | 89,750 | Common | SOLE |
| 039697107 | ARDX | ARDELYX INC | $12.6M | 0.74% | 2,286,273 | Common | SOLE |
| 235851102 | DHR | DANAHER CORPORATION | $12.2M | 0.71% | 61,500 | Common | SOLE |
| 52635N103 | LENZ | LENZ THERAPEUTICS INC | $11.0M | 0.64% | 236,227 | Common | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $10.4M | 0.61% | 154,528 | Common | SOLE |
| 26818M108 | DYN | DYNE THERAPEUTICS INC | $10.4M | 0.61% | 824,061 | Common | SOLE |
| 589492107 | MREO | MEREO BIOPHARMA GROUP PLC | $9.4M | 0.55% | 4,570,649 | Common | SOLE |
| 00461U105 | ACRS | ACLARIS THERAPEUTICS INC | $8.8M | 0.51% | 4,609,309 | Common | SOLE |
| 38341P102 | GOSS | GOSSAMER BIO INC | $8.6M | 0.50% | 3,266,960 | Common | SOLE |
| 42238D107 | HTFL | HEARTFLOW INC | $8.4M | 0.49% | 250,000 | Common | SOLE |
| 457730109 | INSP | INSPIRE MED SYS INC | $8.2M | 0.48% | 110,500 | Common | SOLE |
| 00857U107 | AGL | AGILON HEALTH INC | $7.2M | 0.42% | 6,966,300 | Common | SOLE |
| 28176E108 | EW | EDWARDS LIFESCIENCES CORP | $6.8M | 0.40% | 88,000 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $6.8M | 0.40% | 499,764 | Common | SOLE |
| 38341PAA0 | GOSS 5 06/01/27 | GOSSAMER BIO INC | $6.7M | 0.39% | 9,573,000 | Common | SOLE |
| 75886F107 | REGN | REGENERON PHARMACEUTICALS | $6.4M | 0.37% | 11,300 | Common | SOLE |
| 055477103 | BCAX | BICARA THERAPEUTICS INC | $5.9M | 0.34% | 370,666 | Common | SOLE |
| 47103J105 | JANX | JANUX THERAPEUTICS INC | $5.1M | 0.30% | 210,366 | Common | SOLE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $4.9M | 0.29% | 282,624 | Common | SOLE |
| 883556102 | TMO | THERMO FISHER SCIENTIFIC INC | $4.9M | 0.28% | 10,000 | Common | SOLE |
| 10806X102 | BBIO | BRIDGEBIO PHARMA INC | $4.4M | 0.26% | 85,000 | Common | SOLE |
| 02081G201 | ATEC | ALPHATEC HLDGS INC | $4.4M | 0.26% | 302,500 | Common | SOLE |
| 00404A109 | ACHC | ACADIA HEALTHCARE COMPANY IN | $4.2M | 0.25% | 170,000 | Common | SOLE |
| 67576A100 | OCUL | OCULAR THERAPEUTIX INC | $3.5M | 0.20% | 300,000 | Common | SOLE |
| 00444T209 | TLPH | TALPHERA INC | $3.2M | 0.19% | 3,589,186 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $3.2M | 0.19% | 106,537 | Common | SOLE |
| 829401108 | SION | SIONNA THERAPEUTICS INC | $2.9M | 0.17% | 99,429 | Common | SOLE |
| 268311107 | EDAP | EDAP TMS S A | $2.9M | 0.17% | 1,270,000 | Common | SOLE |
| 471871202 | JSPR | JASPER THERAPEUTICS INC | $2.6M | 0.15% | 1,100,726 | Common | SOLE |
| 955306105 | WST | WEST PHARMACEUTICAL SVSC INC | $2.6M | 0.15% | 9,750 | Common | SOLE |
| 03753U106 | APLSUSD | APELLIS PHARMACEUTICALS INC | $2.1M | 0.12% | 92,000 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $1.8M | 0.11% | 104,339 | Common | SOLE |
| 500946108 | KRRO | KORRO BIO INC | $1.7M | 0.10% | 35,719 | Common | SOLE |
| 152309100 | CNTA | CENTESSA PHARMACEUTICALS PLC | $1.7M | 0.10% | 69,240 | Common | SOLE |
| 46489V302 | CATX | PERSPECTIVE THERAPEUTICS INC | $1.5M | 0.09% | 444,383 | Common | SOLE |
| 03828A101 | APLT | APPLIED THERAPEUTICS INC | $1.3M | 0.07% | 2,075,991 | Common | SOLE |
| 59045L205 | MRSN | MERSANA THERAPEUTICS INC | $1.2M | 0.07% | 152,586 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $1.2M | 0.07% | 72,965 | Common | SOLE |
| N62509109 | NAMS | NEWAMSTERDAM PHARMA COMPANY | $898,704 | 0.05% | 31,600 | CALL | SOLE |
| 30233G209 | EYPT | EYEPOINT PHARMACEUTICALS INC | $450,767 | 0.03% | 31,655 | Common | SOLE |
| 159864107 | CRL | CHARLES RIV LABS INTL INC | $422,442 | 0.02% | 2,700 | Common | SOLE |
| 92243G108 | PCVX | VAXCYTE INC | $399,822 | 0.02% | 11,100 | Common | SOLE |
| 670002401 | NVAX | NOVAVAX INC | $390,150 | 0.02% | 45,000 | Common | SOLE |
| G72800108 | PRTA | PROTHENA CORP PLC | $247,884 | 0.01% | 25,398 | Common | SOLE |
| 61559X104 | MLTX | MOONLAKE IMMUNOTHERAPEUTICS | $202,194 | 0.01% | 28,200 | Common | SOLE |
| 67080N119 | NUVB/WS | NUVATION BIO INC | $27,087 | 0.00% | 134,028 | Common | SOLE |
| M25722105 | CGEN | COMPUGEN LTD | $19,742 | 0.00% | 13,430 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.