Q2 2025 · 13F-HR
RTW INVESTMENTS, LPholdings as filed
Filed 2025-08-14 · accession 0001493215-25-000007
$7.02B
Reported value
73
Positions
2025-06-30
Period end
The Brief · RTW INVESTMENTS, LP · Q2 2025
AI · grounded in 13F
RTW INVESTMENTS, LP established a new position in Madrigal Pharmaceuticals Inc MDGL valued at $603.4M. The fund also initiated new stakes in Natera Inc NTRA for $438.2M and PTC Therapeutics Inc PTCT for $378.3M. Other new additions include Argenx SE ARGX and Protagonist Therapeutics Inc PTGX.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 558868105 | MDGL | MADRIGAL PHARMACEUTICALS INC | $603.4M | 8.59% | 1,993,687 | Common | SOLE |
| 632307104 | NTRA | NATERA INC | $438.2M | 6.24% | 2,593,645 | Common | SOLE |
| 69366J200 | PTCT | PTC THERAPEUTICS INC | $378.3M | 5.39% | 7,746,415 | Common | SOLE |
| 04016X101 | ARGX | ARGENX SE | $371.2M | 5.29% | 673,497 | Common | SOLE |
| 74366E102 | PTGX | PROTAGONIST THERAPEUTICS INC | $318.1M | 4.53% | 5,756,277 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $310.4M | 4.42% | 3,084,558 | Common | SOLE |
| 00973Y108 | AKRO | AKERO THERAPEUTICS INC | $292.3M | 4.16% | 5,477,561 | Common | SOLE |
| 925050106 | VRNA | VERONA PHARMA PLC | $288.6M | 4.11% | 3,051,878 | Common | SOLE |
| 05370A108 | RNAGBP | AVIDITY BIOSCIENCES INC | $273.2M | 3.89% | 9,618,845 | Common | SOLE |
| 863667101 | SYK | STRYKER CORPORATION | $233.6M | 3.33% | 590,517 | Common | SOLE |
| 70975L107 | PEN | PENUMBRA INC | $221.6M | 3.16% | 863,553 | Common | SOLE |
| N5749R100 | 2GH | MERUS N V | $210.4M | 3.00% | 4,000,553 | Common | SOLE |
| 004225108 | ACAD | ACADIA PHARMACEUTICALS INC | $194.0M | 2.76% | 8,995,547 | Common | SOLE |
| 98887Q104 | ZLAB | ZAI LAB LTD | $193.6M | 2.76% | 5,536,876 | Common | SOLE |
| 05464T104 | AXSM | AXSOME THERAPEUTICS INC | $158.3M | 2.26% | 1,516,903 | Common | SOLE |
| 750491102 | RDNT | RADNET INC | $153.1M | 2.18% | 2,690,344 | Common | SOLE |
| 45258D105 | IMCR | IMMUNOCORE HLDGS PLC | $152.8M | 2.18% | 4,869,798 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $134.0M | 1.91% | 4,682,289 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $133.5M | 1.90% | 1,062,072 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $126.1M | 1.80% | 3,111,680 | Common | SOLE |
| 03770N101 | APGE | APOGEE THERAPEUTICS INC | $117.8M | 1.68% | 2,712,097 | Common | SOLE |
| 574795100 | MASI | MASIMO CORP | $114.9M | 1.64% | 683,294 | Common | SOLE |
| G31249108 | ESTA | ESTABLISHMENT LABS HLDGS INC | $110.4M | 1.57% | 2,584,131 | Common | SOLE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $110.0M | 1.57% | 202,456 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $89.9M | 1.28% | 2,721,158 | Common | SOLE |
| 74834L100 | DGX | QUEST DIAGNOSTICS INC | $89.8M | 1.28% | 500,000 | Common | SOLE |
| N90064101 | QURE | UNIQURE NV | $71.9M | 1.02% | 5,158,231 | Common | SOLE |
| G3855L106 | GHRS | GH RESEARCH PLC | $67.5M | 0.96% | 5,540,457 | Common | SOLE |
| M96088105 | URGN | UROGEN PHARMA LTD | $62.3M | 0.89% | 4,543,895 | Common | SOLE |
| 90400D108 | RARE | ULTRAGENYX PHARMACEUTICAL IN | $62.1M | 0.88% | 1,707,402 | Common | SOLE |
| 002824100 | ABT | ABBOTT LABS | $60.4M | 0.86% | 444,000 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $58.2M | 0.83% | 5,123,525 | Common | SOLE |
| 877619106 | TSHA | TAYSHA GENE THERAPIES INC | $57.8M | 0.82% | 25,021,584 | Common | SOLE |
| 00773J202 | SYRE | SPYRE THERAPEUTICS INC | $54.2M | 0.77% | 3,621,996 | Common | SOLE |
| 08659B102 | BBNX | BETA BIONICS INC | $48.0M | 0.68% | 3,299,191 | Common | SOLE |
| 36266G107 | GEHC | GE HEALTHCARE TECHNOLOGIES I | $46.4M | 0.66% | 626,000 | Common | SOLE |
| 40131M109 | GH | GUARDANT HEALTH INC | $44.6M | 0.63% | 856,501 | Common | SOLE |
| 156944100 | CGON | CG ONCOLOGY INC | $44.2M | 0.63% | 1,701,216 | Common | SOLE |
| 77313F106 | RCKT | ROCKET PHARMACEUTICALS INC | $43.3M | 0.62% | 17,687,772 | Common | SOLE |
| N44445109 | IMTX | IMMATICS N.V | $37.5M | 0.53% | 6,970,152 | Common | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $35.6M | 0.51% | 424,408 | Common | SOLE |
| 61559X104 | MLTX | MOONLAKE IMMUNOTHERAPEUTICS | $35.0M | 0.50% | 741,090 | Common | SOLE |
| 88023B103 | TEM | TEMPUS AI INC | $25.4M | 0.36% | 400,000 | Common | SOLE |
| 52635N103 | LENZ | LENZ THERAPEUTICS INC | $25.3M | 0.36% | 863,389 | Common | SOLE |
| 20451W101 | CMPS | COMPASS PATHWAYS PLC | $23.0M | 0.33% | 8,221,929 | Common | SOLE |
| 68572M106 | OBIO | ORCHESTRA BIOMED HLDGS INC | $22.3M | 0.32% | 8,306,062 | Common | SOLE |
| 687604108 | ORKA | ORUKA THERAPEUTICS INC | $21.8M | 0.31% | 1,945,649 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $20.4M | 0.29% | 1,362,456 | Common | SOLE |
| 152309100 | CNTA | CENTESSA PHARMACEUTICALS PLC | $20.1M | 0.29% | 1,529,836 | Common | SOLE |
| 282559103 | ETNBGBP | 89BIO INC | $19.3M | 0.28% | 1,967,527 | Common | SOLE |
| 76029N106 | REPL | REPLIMUNE GROUP INC | $19.2M | 0.27% | 2,065,010 | Common | SOLE |
| 98401F105 | XNCR | XENCOR INC | $18.9M | 0.27% | 2,402,883 | Common | SOLE |
| 92337C203 | VSTM | VERASTEM INC | $17.6M | 0.25% | 4,251,616 | Common | SOLE |
| 26818M108 | DYN | DYNE THERAPEUTICS INC | $16.1M | 0.23% | 1,690,567 | Common | SOLE |
| 008064206 | JBIO | JADE BIOSCIENCES INC | $14.5M | 0.21% | 1,449,273 | Common | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $13.4M | 0.19% | 467,000 | Common | SOLE |
| 230031106 | CGEM | CULLINAN THERAPEUTICS INC | $12.8M | 0.18% | 1,705,960 | Common | SOLE |
| 30068X103 | XGN | EXAGEN INC | $11.8M | 0.17% | 1,696,866 | Common | SOLE |
| 75382E208 | RAPT | RAPT THERAPEUTICS INC | $11.8M | 0.17% | 1,470,499 | Common | SOLE |
| 221015100 | CRVS | CORVUS PHARMACEUTICALS INC | $10.7M | 0.15% | 2,679,479 | Common | SOLE |
| G70077105 | PCSC | PERCEPTIVE CAP SOLUTIONS COR | $7.9M | 0.11% | 742,500 | Common | SOLE |
| 23284F105 | CTMX | CYTOMX THERAPEUTICS INC | $7.9M | 0.11% | 3,461,500 | Common | SOLE |
| 02008G201 | ALUR | ALLURION TECHNOLOGIES INC | $6.2M | 0.09% | 2,542,603 | Common | SOLE |
| Y95308105 | WVE | WAVE LIFE SCIENCES LTD | $5.8M | 0.08% | 900,000 | Common | SOLE |
| 14179K101 | CRGX | CARGO THERAPEUTICS INC | $5.0M | 0.07% | 1,212,562 | Common | SOLE |
| 59935V107 | MIST | MILESTONE PHARMACEUTICALS IN | $4.9M | 0.07% | 2,506,102 | Common | SOLE |
| 68170A108 | OMDA | OMADA HEALTH INC | $3.7M | 0.05% | 200,000 | Common | SOLE |
| G52441105 | KMTS | KESTRA MED TECHNOLOGIES LTD | $3.3M | 0.05% | 200,000 | Common | SOLE |
| 15678C102 | CBLL | CERIBELL INC | $2.8M | 0.04% | 150,000 | Common | SOLE |
| 88032L605 | TENX | TENAX THERAPEUTICS INC | $2.2M | 0.03% | 378,346 | Common | SOLE |
| 4525EP101 | VTLUSD | IMMUNIC INC | $280,470 | 0.00% | 402,107 | Common | SOLE |
| 00534B100 | ADGM | ADAGIO MED HLDGS INC | $272,169 | 0.00% | 209,361 | Common | SOLE |
| 77313F114 | RCKTW | ROCKET PHARMACEUTICALS INC | $10,080 | 0.00% | 350,000 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.