Q4 2025 · 13F-HR
RTW INVESTMENTS, LPholdings as filed
Filed 2026-02-17 · accession 0001493215-26-000060
$9.98B
Reported value
91
Positions
2025-12-31
Period end
The Brief · RTW INVESTMENTS, LP · Q4 2025
AI · grounded in 13F
RTW INVESTMENTS, LP closed its position in Avidity Biosciences Inc RNAGBP, reducing exposure by $495.5M. The fund also exited positions in Akero Therapeutics Inc AKRO and Merus N V, totaling over $450M in combined sales. On the buy side, the fund established new positions in iRhythm Technologies Inc IRTC for $209.7M and Apellis Pharmaceuticals Inc APLSUSD for $192.6M. Additionally, the fund increased its holdings in Cogent Biosciences Inc COGT by 118.9% and Insmed Inc INSM by 57%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 558868105 | MDGL | MADRIGAL PHARMACEUTICALS INC | $1.16B | 11.6% | 1,993,687 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $842.9M | 8.44% | 4,842,879 | Common | SOLE |
| 69366J200 | PTCT | PTC THERAPEUTICS INC | $588.4M | 5.89% | 7,746,415 | Common | SOLE |
| 04016X101 | ARGX | ARGENX SE | $566.4M | 5.67% | 673,497 | Common | SOLE |
| 74366E102 | PTGX | PROTAGONIST THERAPEUTICS INC | $441.9M | 4.43% | 5,059,053 | Common | SOLE |
| 632307104 | NTRA | NATERA INC | $343.6M | 3.44% | 1,500,000 | Common | SOLE |
| 750491102 | RDNT | RADNET INC | $281.0M | 2.81% | 3,938,500 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $273.1M | 2.74% | 3,335,320 | Common | SOLE |
| 19240Q201 | COGT | COGENT BIOSCIENCES INC | $269.7M | 2.70% | 7,592,241 | Common | SOLE |
| 70975L107 | PEN | PENUMBRA INC | $269.4M | 2.70% | 866,499 | Common | SOLE |
| 450056106 | IRTC | IRHYTHM TECHNOLOGIES INC | $209.7M | 2.10% | 1,181,990 | Common | SOLE |
| 03770N101 | APGE | APOGEE THERAPEUTICS INC | $204.7M | 2.05% | 2,712,097 | Common | SOLE |
| 03753U106 | APLSUSD | APELLIS PHARMACEUTICALS INC | $192.6M | 1.93% | 7,666,764 | Common | SOLE |
| 004225108 | ACAD | ACADIA PHARMACEUTICALS INC | $190.8M | 1.91% | 7,144,524 | Common | SOLE |
| G31249108 | ESTA | ESTABLISHMENT LABS HLDGS INC | $188.7M | 1.89% | 2,588,831 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $176.1M | 1.76% | 5,546,856 | Common | SOLE |
| 759916109 | RGEN | REPLIGEN CORP | $174.3M | 1.75% | 1,064,000 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $172.9M | 1.73% | 2,721,158 | Common | SOLE |
| 45258D105 | IMCR | IMMUNOCORE HLDGS PLC | $169.0M | 1.69% | 4,869,798 | Common | SOLE |
| 05464T104 | AXSM | AXSOME THERAPEUTICS INC | $162.2M | 1.62% | 888,001 | Common | SOLE |
| 40131M109 | GH | GUARDANT HEALTH INC | $151.3M | 1.52% | 1,481,033 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $150.6M | 1.51% | 1,062,072 | Common | SOLE |
| 00773J202 | SYRE | SPYRE THERAPEUTICS INC | $136.7M | 1.37% | 4,171,996 | Common | SOLE |
| 98887Q104 | ZLAB | ZAI LAB LTD | $122.8M | 1.23% | 6,959,032 | Common | SOLE |
| N44445109 | IMTX | IMMATICS N.V | $120.1M | 1.20% | 11,433,354 | Common | SOLE |
| 07782B104 | BLTE | BELITE BIO INC | $114.4M | 1.15% | 715,332 | Common | SOLE |
| M96088105 | URGN | UROGEN PHARMA LTD | $106.4M | 1.07% | 4,543,895 | Common | SOLE |
| 98401F105 | XNCR | XENCOR INC | $103.8M | 1.04% | 6,777,461 | Common | SOLE |
| 45784P101 | PODD | INSULET CORP | $92.3M | 0.92% | 324,600 | Common | SOLE |
| 877619106 | TSHA | TAYSHA GENE THERAPIES INC | $90.2M | 0.90% | 16,398,297 | Common | SOLE |
| 574795100 | MASI | MASIMO CORP | $88.9M | 0.89% | 683,294 | Common | SOLE |
| N90064101 | QURE | UNIQURE NV | $88.8M | 0.89% | 3,711,462 | Common | SOLE |
| 863667101 | SYK | STRYKER CORPORATION | $86.1M | 0.86% | 245,000 | Common | SOLE |
| 156944100 | CGON | CG ONCOLOGY INC | $83.5M | 0.84% | 2,012,127 | Common | SOLE |
| 14843C105 | CSTL | CASTLE BIOSCIENCES INC | $82.3M | 0.82% | 2,115,237 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $80.8M | 0.81% | 3,177,850 | Common | SOLE |
| 08659B102 | BBNX | BETA BIONICS INC | $76.2M | 0.76% | 2,500,000 | Common | SOLE |
| G3855L106 | GHRS | GH RESEARCH PLC | $75.4M | 0.75% | 5,933,815 | Common | SOLE |
| 76029N106 | REPL | REPLIMUNE GROUP INC | $69.4M | 0.70% | 7,140,352 | Common | SOLE |
| 90400D108 | RARE | ULTRAGENYX PHARMACEUTICAL IN | $69.0M | 0.69% | 3,000,139 | Common | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $62.9M | 0.63% | 1,351,326 | Common | SOLE |
| 687604108 | ORKA | ORUKA THERAPEUTICS INC | $62.4M | 0.62% | 2,058,148 | Common | SOLE |
| 77313F106 | RCKT | ROCKET PHARMACEUTICALS INC | $62.1M | 0.62% | 17,687,772 | Common | SOLE |
| 20451W101 | CMPS | COMPASS PATHWAYS PLC | $60.4M | 0.61% | 8,757,390 | Common | SOLE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $57.3M | 0.57% | 101,228 | Common | SOLE |
| 75382E208 | RAPT | RAPT THERAPEUTICS INC | $55.5M | 0.56% | 1,637,165 | Common | SOLE |
| 15102K100 | CELC | CELCUITY INC | $54.9M | 0.55% | 550,160 | Common | SOLE |
| 92337C203 | VSTM | VERASTEM INC | $50.8M | 0.51% | 6,576,306 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $46.8M | 0.47% | 1,672,356 | Common | SOLE |
| 152309100 | CNTA | CENTESSA PHARMACEUTICALS PLC | $44.8M | 0.45% | 1,790,837 | Common | SOLE |
| 50015M109 | KOD | KODIAK SCIENCES INC | $41.6M | 0.42% | 1,487,933 | Common | SOLE |
| 03843E104 | AQST | AQUESTIVE THERAPEUTICS INC | $40.4M | 0.40% | 6,250,000 | Common | SOLE |
| 04280A100 | ARWR | ARROWHEAD PHARMACEUTICALS IN | $38.8M | 0.39% | 584,716 | Common | SOLE |
| 805111101 | SVRA | SAVARA INC | $35.9M | 0.36% | 5,952,380 | Common | SOLE |
| 68572M106 | OBIO | ORCHESTRA BIOMED HLDGS INC | $34.5M | 0.35% | 8,306,063 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $28.1M | 0.28% | 1,362,456 | Common | SOLE |
| Y95308105 | WVE | WAVE LIFE SCIENCES LTD | $22.9M | 0.23% | 1,350,000 | Common | SOLE |
| 008064206 | JBIO | JADE BIOSCIENCES INC | $22.4M | 0.22% | 1,449,273 | Common | SOLE |
| 30054Y107 | EVMN | EVOMMUNE INC | $22.0M | 0.22% | 1,283,671 | Common | SOLE |
| 501575104 | KYMR | KYMERA THERAPEUTICS INC | $18.7M | 0.19% | 240,000 | Common | SOLE |
| 359664109 | FLGT | FULGENT GENETICS INC | $18.5M | 0.19% | 705,027 | Common | SOLE |
| 230031106 | CGEM | CULLINAN THERAPEUTICS INC | $17.7M | 0.18% | 1,705,960 | Common | SOLE |
| 433313103 | HNGE | HINGE HEALTH INC | $16.4M | 0.16% | 353,500 | Common | SOLE |
| 07373V105 | BEAM | BEAM THERAPEUTICS INC | $15.8M | 0.16% | 570,394 | Common | SOLE |
| 42238D107 | HTFL | HEARTFLOW INC | $14.4M | 0.14% | 495,000 | Common | SOLE |
| 20454B104 | CMPX | COMPASS THERAPEUTICS INC | $13.4M | 0.13% | 2,500,000 | Common | SOLE |
| 87583X109 | TNGX | TANGO THERAPEUTICS INC | $13.2M | 0.13% | 1,491,228 | Common | SOLE |
| 550249106 | LMRI | LUMEXA IMAGING HOLDINGS INC | $12.0M | 0.12% | 650,000 | Common | SOLE |
| 517125100 | LRMR | LARIMAR THERAPEUTICS INC | $11.9M | 0.12% | 3,125,000 | Common | SOLE |
| 88023B103 | TEM | TEMPUS AI INC | $11.8M | 0.12% | 200,000 | Common | SOLE |
| 482929106 | KLRS | KALARIS THERAPEUTICS INC | $11.0M | 0.11% | 1,300,000 | Common | SOLE |
| 46266C105 | IQV | IQVIA HLDGS INC | $10.4M | 0.10% | 46,000 | Common | SOLE |
| G70077105 | PCSC | PERCEPTIVE CAP SOLUTIONS COR | $9.7M | 0.10% | 742,500 | Common | SOLE |
| N0731H103 | ATAI | ATAI BECKLEY NV | $8.2M | 0.08% | 2,000,000 | Common | SOLE |
| 02008G201 | ALUR | ALLURION TECHNOLOGIES INC | $7.2M | 0.07% | 5,891,430 | Common | SOLE |
| 14070B309 | CAPR | CAPRICOR THERAPEUTICS INC | $7.2M | 0.07% | 250,000 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $7.0M | 0.07% | 100,000 | Common | SOLE |
| 46124U107 | IVA | INVENTIVA SA | $6.0M | 0.06% | 1,298,701 | Common | SOLE |
| 59935V107 | MIST | MILESTONE PHARMACEUTICALS IN | $5.1M | 0.05% | 2,506,102 | Common | SOLE |
| 30068X103 | XGN | EXAGEN INC | $4.8M | 0.05% | 790,462 | Common | SOLE |
| 88032L605 | TENX | TENAX THERAPEUTICS INC | $4.6M | 0.05% | 378,346 | Common | SOLE |
| G2545C104 | CBIO | CRESCENT BIOPHARMA INC. | $4.4M | 0.04% | 372,856 | Common | SOLE |
| 60255C885 | BRD1EUR | MIND MEDICINE MINDMED INC | $4.0M | 0.04% | 300,000 | Common | SOLE |
| 35104E100 | FDMT | 4D MOLECULAR THERAPEUTICS IN | $3.6M | 0.04% | 475,737 | Common | SOLE |
| 221015100 | CRVS | CORVUS PHARMACEUTICALS INC | $3.4M | 0.03% | 447,607 | Common | SOLE |
| 68170A108 | OMDA | OMADA HEALTH INC | $3.2M | 0.03% | 200,000 | Common | SOLE |
| 58507V107 | MDLN | MEDLINE INC | $2.9M | 0.03% | 70,000 | Common | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $2.4M | 0.02% | 30,000 | Common | SOLE |
| 45175G207 | IMA | IMAGENEBIO INC | $2.3M | 0.02% | 334,445 | Common | SOLE |
| 29479A108 | ERAS | ERASCA INC | $545,542 | 0.01% | 146,651 | Common | SOLE |
| 77313F114 | RCKTW | ROCKET PHARMACEUTICALS INC | $8,505 | 0.00% | 350,000 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.