Q4 2025 · 13F-HR
Knott David M Jrholdings as filed
Filed 2026-02-12 · accession 0001104659-26-014058
$215.9M
Reported value
87
Positions
2025-12-31
Period end
The Brief · Knott David M Jr · Q4 2025
AI · grounded in 13F
Knott David M Jr closed its position in Darling Ingredients Inc. DAR, reducing exposure by $9.26M. The fund also exited positions in Avadel Pharmaceuticals plc AVDL and Verona Pharma PLC VRNA, which decreased holdings by $5.54M and $4.09M respectively. On the buy side, the fund established a new position in Cogent Biosciences Inc. COGT worth $3.62M and increased its stake in Alkermes PLC ALKS by 392.23%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 131428104 | CLMT | Calumet, Inc. | $44.0M | 20.4% | 2,214,969 | Common | SOLE |
| 03769M106 | APO | Apollo Global Management, Inc. | $32.6M | 15.1% | 225,000 | Common | SOLE |
| 02079K107 | GOOG | Alphabet Inc-Cl C | $28.7M | 13.3% | 91,420 | Common | SOLE |
| 87164F105 | SNDX | Syndax Pharmaceutical, Inc. | $8.7M | 4.04% | 415,000 | Common | SOLE |
| 98422E103 | XERS | Xeris Biopharma Holdings, Inc. | $7.6M | 3.53% | 970,000 | Common | SOLE |
| 89422G107 | TVTX | Travere Therapeutics, Inc. | $7.1M | 3.29% | 186,000 | Common | SOLE |
| 10806X102 | BBIO | Bridgebio Pharma, Inc. | $6.5M | 3.01% | 85,000 | Common | SOLE |
| 74366E102 | PTGX | Protagonist Therapeutics, Inc | $6.4M | 2.95% | 73,000 | Common | SOLE |
| 46625H100 | JPM | JPMorgan Chase & Co. | $6.3M | 2.91% | 19,477 | Common | SOLE |
| 47103U845 | JAAA | Janus Henderson AAA CLO ETF | $4.7M | 2.19% | 93,528 | Common | SOLE |
| 92790C104 | VRDN | Viridian Therapeutics, Inc. | $4.5M | 2.09% | 145,000 | Common | SOLE |
| 14888U101 | CPRX | Catalyst Pharmaceuticals, Inc. | $4.4M | 2.04% | 189,000 | Common | SOLE |
| 19240Q201 | COGT | Cogent Biosciences Inc. | $3.6M | 1.68% | 102,000 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences, Inc. | $2.9M | 1.34% | 121,241 | Common | SOLE |
| G01767105 | ALKS | Alkermes PLC | $2.7M | 1.23% | 95,000 | Common | SOLE |
| 256086109 | DCGO | DocGo, Inc. | $2.3M | 1.09% | 2,670,850 | Common | SOLE |
| 23256X407 | HELP | Cybin Inc | $2.3M | 1.08% | 285,182 | Common | SOLE |
| 23282W605 | CYTK | Cytokinetics, Incorporated | $2.2M | 1.00% | 34,000 | Common | SOLE |
| 04963C209 | ATRC | AtriCure, Inc. | $2.0M | 0.94% | 51,400 | Common | SOLE |
| 01881G106 | AB | AllianceBernstein Holding L.P. | $1.8M | 0.86% | 48,000 | Common | SOLE |
| 03940c100 | — | Arcellx Inc | $1.7M | 0.78% | 25,700 | Common | SOLE |
| 78464A870 | XBI | SPDR S&P Biotech ETF | $1.6M | 0.73% | 13,000 | Common | SOLE |
| 878972108 | TECX | Tectonic Therapeutic, Inc. | $1.5M | 0.71% | 74,000 | Common | SOLE |
| Y95308105 | WVE | Wave Life Science Ltd. | $1.5M | 0.71% | 90,000 | Common | SOLE |
| 478160104 | JNJ | Johnson & Johnson | $1.4M | 0.66% | 6,922 | Common | SOLE |
| 88322Q108 | TGTX | TG Therapeutics, Inc. | $1.3M | 0.62% | 45,000 | Common | SOLE |
| 92337R101 | VERA | Vera Therapeutics, Inc. | $1.3M | 0.61% | 26,000 | Common | SOLE |
| 81752T528 | CLOZ | The Panagram BBB-B CLO ETF | $1.3M | 0.59% | 47,807 | Common | SOLE |
| G1110E107 | BHVN | Biohaven LTD | $1.3M | 0.58% | 110,720 | Common | SOLE |
| 110122108 | BMY | Bristol-Myers Squibb Company | $1.2M | 0.55% | 22,000 | Common | SOLE |
| 558868105 | MDGL | Madrigal Pharmaaceuticals, Inc. | $1.2M | 0.54% | 2,000 | Common | SOLE |
| 000899104 | ADMA | ADMA Biologics, Inc. | $1.1M | 0.51% | 60,200 | Common | SOLE |
| 09062X103 | BIIB | Biogen Inc. | $1.1M | 0.49% | 6,000 | Common | SOLE |
| 68572M106 | OBIO | Orchestra Biomed Holdings, Inc. | $1.0M | 0.48% | 250,000 | Common | SOLE |
| 464287556 | IBB | iShares Biotechnology ETF | $928,235 | 0.43% | 5,500 | Common | SOLE |
| 83422E204 | SLDB | Solid Bioscience Inc. | $916,162 | 0.42% | 162,440 | Common | SOLE |
| 52635N103 | LENZ | LENZ Therapeutics, Inc. | $859,712 | 0.40% | 53,732 | Common | SOLE |
| 717081103 | PFE | Pfizer Inc. | $805,191 | 0.37% | 32,337 | Common | SOLE |
| 76200L309 | RZLT | Rezolute, Inc. | $802,400 | 0.37% | 340,000 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corporation | $773,792 | 0.36% | 1,600 | Common | SOLE |
| 037833100 | AAPL | Apple Inc. | $678,019 | 0.31% | 2,494 | Common | SOLE |
| 30052c107 | — | Evolus, Inc. | $660,598 | 0.31% | 99,338 | Common | SOLE |
| 640268306 | NKTR | Nektar Therapeutics | $655,340 | 0.30% | 15,500 | Common | SOLE |
| 459200101 | IBM | International Business Machines | $634,482 | 0.29% | 2,142 | Common | SOLE |
| 80706P103 | SRRK | Scholar Rock Holding Corporation | $612,868 | 0.28% | 13,913 | Common | SOLE |
| 171126204 | PTHS | Pelthos Therapeutics, Inc. | $597,711 | 0.28% | 19,281 | Common | SOLE |
| 136385101 | CNQ | Canadian Natural Resources Limited | $568,680 | 0.26% | 16,800 | Common | SOLE |
| G23549101 | CNTB | Connect Biopharma Holdings Limited | $564,000 | 0.26% | 200,000 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc. | $491,317 | 0.23% | 10,962 | Common | SOLE |
| 00847X104 | AGIO | Agios Pharmaceutical, Inc. | $489,960 | 0.23% | 18,000 | Common | SOLE |
| 90400D108 | RARE | Ultragenyx Pharmaceutical Inc. | $460,138 | 0.21% | 20,006 | Common | SOLE |
| 59045L205 | MRSN | Rain Enhancement Technologies Holdco Inc | $437,762 | 0.20% | 111,686 | Common | SOLE |
| 50127T109 | KURA | Kura Oncology, Inc. | $407,382 | 0.19% | 39,209 | Common | SOLE |
| 31189P102 | FATE | Fate Therapeutics, Inc. | $358,649 | 0.17% | 365,000 | Common | SOLE |
| 471871202 | JSPR | Jasper Therapeutics, Inc. | $331,942 | 0.15% | 181,389 | Common | SOLE |
| 00534A102 | IVVD | Invivyd, Inc. | $247,000 | 0.11% | 100,000 | Common | SOLE |
| 11135F101 | AVGO | Broadcom, Inc. | $245,731 | 0.11% | 710 | Common | SOLE |
| 494368103 | KMB | Kimberly-Clark Corporation | $242,136 | 0.11% | 2,400 | Common | SOLE |
| 23954D109 | DAWNGBX | Day One Biopharmaceuticals, Inc. | $241,239 | 0.11% | 25,884 | Common | SOLE |
| 67066G104 | NVDA | Nvidia Corp | $238,720 | 0.11% | 1,280 | Common | SOLE |
| 78377T107 | RHP | Ryman Hospitality Properties, Inc. | $227,088 | 0.11% | 2,400 | Common | SOLE |
| 609207105 | MDLZ | Mondelez International Inc. | $161,430 | 0.07% | 3,000 | Common | SOLE |
| 26614N102 | DD | DuPont de Nemours, Inc. | $151,433 | 0.07% | 3,767 | Common | SOLE |
| 589492107 | MREO | Mereo BioPharm Group PLC | $125,150 | 0.06% | 300,337 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $100,040 | 0.05% | 4,000 | Common | SOLE |
| N90064101 | QURE | uniQure N.V. | $95,720 | 0.04% | 4,000 | Common | SOLE |
| 464287481 | IWP | iShares Russell Mid-Cap Growth | $95,173 | 0.04% | 695 | Common | SOLE |
| 02079k305 | — | Alphabet Inc CL A | $93,900 | 0.04% | 300 | Common | SOLE |
| 27627N105 | EBC | Eastern Bankshares Inc | $92,150 | 0.04% | 5,000 | Common | SOLE |
| 22052L104 | CTVA | Corteva, Inc. | $80,838 | 0.04% | 1,206 | Common | SOLE |
| 52472M101 | LEGH | Legacy Housing Corporation | $78,080 | 0.04% | 4,000 | Common | SOLE |
| 74762E102 | QURE | Quanta Services, Inc. | $74,283 | 0.03% | 176 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc. | $69,246 | 0.03% | 300 | Common | SOLE |
| 911363109 | URI | United Rental, Inc. | $63,127 | 0.03% | 78 | Common | SOLE |
| 302635206 | FSK | FS KKR Capital Corp. | $42,579 | 0.02% | 2,875 | Common | SOLE |
| 235851102 | DHR | Danaher Corporation | $41,206 | 0.02% | 180 | Common | SOLE |
| 459902102 | — | International Game Technology PLC | $38,700 | 0.02% | 2,500 | Common | SOLE |
| 09260d107 | — | Blackstone Group LP | $32,369 | 0.01% | 210 | Common | SOLE |
| 260557103 | DOW | Dow Inc. | $28,196 | 0.01% | 1,206 | Common | SOLE |
| 883556102 | TMO | Thermo Fisher Scientific, Inc. | $26,075 | 0.01% | 45 | Common | SOLE |
| 674599105 | OXY | Occidential Pertro Wts exp. 8/3/27 | $23,553 | 0.01% | 663 | Common | SOLE |
| 79466L302 | CRM | Salesforce, Inc. | $20,398 | 0.01% | 77 | Common | SOLE |
| 91324p102 | — | United Healthcare Corp. | $18,816 | 0.01% | 57 | Common | SOLE |
| 50155Q100 | KD | Kyndryl Holdings Inc. | $11,368 | 0.01% | 428 | Common | SOLE |
| 85571B105 | STWD | Starwood Property Trust, Inc. | $7,204 | 0.00% | 400 | Common | SOLE |
| 36266G107 | GEHC | GE HealthCare Technologies Inc | $4,101 | 0.00% | 50 | Common | SOLE |
| 929740108 | WAB | Wabtec Corporation | $1,281 | 0.00% | 6 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.