Q4 2024 · 13F-HR
ORBIMED ADVISORS LLCholdings as filed
Filed 2025-02-14 · accession 0001172661-25-001136
$4.86B
Reported value
118
Positions
2024-12-31
Period end
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $401.1M | 8.25% | 15,021,721 | Common | SOLE |
| P8696W104 | SVA | SINOVAC BIOTECH LTD | $334.0M | 6.87% | 2,718,735 | Common | NONE |
| 101137107 | BSX | BOSTON SCIENTIFIC CORP | $282.3M | 5.81% | 3,160,300 | Common | NONE |
| 532457108 | LLY | ELI LILLY & CO | $260.6M | 5.36% | 337,600 | Common | NONE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $209.7M | 4.31% | 401,700 | Common | NONE |
| 29337E102 | ELVN | ENLIVEN THERAPEUTICS INC | $179.1M | 3.68% | 7,959,538 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $128.1M | 2.63% | 938,120 | Common | NONE |
| 863667101 | SYK | STRYKER CORPORATION | $124.0M | 2.55% | 344,400 | Common | NONE |
| 803607100 | SRPT | SAREPTA THERAPEUTICS INC | $117.1M | 2.41% | 963,400 | Common | NONE |
| 04016X101 | ARGX | ARGENX SE | $116.7M | 2.40% | 189,700 | Common | NONE |
| 254604101 | IRON | DISC MEDICINE INC | $113.2M | 2.33% | 1,785,571 | Common | SOLE |
| 88033G407 | THC | TENET HEALTHCARE CORP | $100.0M | 2.06% | 792,000 | Common | NONE |
| 462222100 | IONS | IONIS PHARMACEUTICALS INC | $98.5M | 2.03% | 2,817,347 | Common | NONE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $97.8M | 2.01% | 415,600 | Common | NONE |
| 91678A107 | UPB | UPSTREAM BIO INC | $93.6M | 1.93% | 5,693,589 | Common | SOLE |
| 82835W108 | SPRY | ARS PHARMACEUTICALS INC | $87.4M | 1.80% | 8,288,510 | Common | SOLE |
| 28176E108 | EW | EDWARDS LIFESCIENCES CORP | $84.8M | 1.74% | 1,145,302 | Common | NONE |
| 58933Y105 | MRK | MERCK & CO INC | $82.6M | 1.70% | 829,900 | Common | NONE |
| 04272N102 | AVBP | ARRIVENT BIOPHARMA INC | $80.6M | 1.66% | 3,027,328 | Common | SOLE |
| 09062X103 | BIIB | BIOGEN INC | $77.9M | 1.60% | 509,100 | Common | NONE |
| 45826H109 | ITGR | INTEGER HLDGS CORP | $76.2M | 1.57% | 575,000 | Common | NONE |
| 23282W605 | CYTK | CYTOKINETICS INC | $74.5M | 1.53% | 1,584,005 | Common | NONE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $70.3M | 1.45% | 3,812,215 | Common | SOLE |
| 91324P102 | UNH | UNITEDHEALTH GROUP INC | $66.2M | 1.36% | 130,900 | Common | NONE |
| 632307104 | NTRA | NATERA INC | $65.4M | 1.34% | 413,000 | Common | NONE |
| 92532F100 | VRTX | VERTEX PHARMACEUTICALS INC | $60.8M | 1.25% | 151,000 | Common | NONE |
| 88427A107 | — | THIRD HARMONIC BIO INC | $59.5M | 1.22% | 5,779,071 | Common | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $51.1M | 1.05% | 999,000 | Common | SOLE |
| 913903100 | UHS | UNIVERSAL HLTH SVCS INC | $48.3M | 0.99% | 269,300 | Common | NONE |
| 825704109 | SIBN | SI-BONE INC | $48.3M | 0.99% | 3,442,853 | Common | NONE |
| 85205L107 | SWTXUSD | SPRINGWORKS THERAPEUTICS INC | $45.3M | 0.93% | 1,255,031 | Common | SOLE |
| 883556102 | TMO | THERMO FISHER SCIENTIFIC INC | $43.9M | 0.90% | 84,400 | Common | NONE |
| 880881107 | 430 | TERNS PHARMACEUTICALS INC | $41.9M | 0.86% | 7,562,971 | Common | SOLE |
| 156944100 | CGON | CG ONCOLOGY INC | $41.0M | 0.84% | 1,431,114 | Common | NONE |
| 47103J105 | JANX | JANUX THERAPEUTICS INC | $40.6M | 0.84% | 758,566 | Common | SOLE |
| 30063P105 | EXK | EXACT SCIENCES CORP | $38.2M | 0.79% | 679,816 | Common | NONE |
| 641288105 | NPCE | NEUROPACE INC | $38.1M | 0.78% | 3,406,335 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $37.2M | 0.76% | 947,877 | Common | NONE |
| 221015100 | CRVS | CORVUS PHARMACEUTICALS INC | $37.1M | 0.76% | 6,943,654 | Common | SOLE |
| 78464A870 | XBI | SPDR SER TR | $33.5M | 0.69% | 372,000 | Common | NONE |
| 20454B104 | CMPX | COMPASS THERAPEUTICS INC | $32.4M | 0.67% | 22,362,850 | Common | SOLE |
| 98420P308 | XTNT | XTANT MED HLDGS INC | $32.4M | 0.67% | 73,114,592 | Common | SOLE |
| 05370A108 | RNAGBP | AVIDITY BIOSCIENCES INC | $32.4M | 0.67% | 1,112,886 | Common | NONE |
| 92337R101 | VERA | VERA THERAPEUTICS INC | $31.4M | 0.65% | 742,572 | Common | NONE |
| 26818M108 | DYN | DYNE THERAPEUTICS INC | $28.9M | 0.59% | 1,227,080 | Common | NONE |
| 230031106 | CGEM | CULLINAN THERAPEUTICS INC | $23.7M | 0.49% | 1,942,555 | Common | NONE |
| 92764N102 | VIR | VIR BIOTECHNOLOGY INC | $23.6M | 0.49% | 3,218,617 | Common | NONE |
| 375558103 | GILD | GILEAD SCIENCES INC | $22.7M | 0.47% | 245,600 | Common | NONE |
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $22.4M | 0.46% | 400,000 | Common | NONE |
| N44445109 | IMTX | IMMATICS N.V | $22.0M | 0.45% | 3,087,462 | Common | NONE |
| 03152W109 | AM6 | AMICUS THERAPEUTICS INC | $21.5M | 0.44% | 2,285,400 | Common | NONE |
| 810648105 | SCPH | SCPHARMACEUTICALS INC | $21.5M | 0.44% | 6,059,528 | Common | SOLE |
| 75382E109 | — | RAPT THERAPEUTICS INC | $20.8M | 0.43% | 13,135,260 | Common | SOLE |
| 90240B106 | TYRA | TYRA BIOSCIENCES INC | $20.4M | 0.42% | 1,470,086 | Common | NONE |
| 603170101 | MLYS | MINERALYS THERAPEUTICS INC | $19.8M | 0.41% | 1,611,637 | Common | NONE |
| 375558103 | GILD | GILEAD SCIENCES INC | $18.5M | 0.38% | 200,000 | CALL | NONE |
| 000000000 | — | PRELUDE THERAPEUTICS INC | $17.7M | 0.36% | 12,048,773 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $17.7M | 0.36% | 652,028 | Common | NONE |
| 492327101 | KROS | KEROS THERAPEUTICS INC | $16.1M | 0.33% | 1,018,734 | Common | SOLE |
| 12529R107 | CCCC | C4 THERAPEUTICS INC | $15.8M | 0.32% | 4,377,900 | Common | NONE |
| 58506Q109 | MEDP | MEDPACE HLDGS INC | $14.9M | 0.31% | 44,900 | Common | NONE |
| 92337C203 | VSTM | VERASTEM INC | $14.8M | 0.30% | 2,862,448 | Common | SOLE |
| 74065P101 | PRLD | PRELUDE THERAPEUTICS INC | $13.9M | 0.29% | 10,909,256 | Common | SOLE |
| 21833P301 | CRBP | CORBUS PHARMACEUTICALS HLDGS | $13.8M | 0.28% | 1,172,287 | Common | NONE |
| 34962G208 | FBRX | FORTE BIOSCIENCES INC | $13.6M | 0.28% | 600,000 | Common | SOLE |
| 46116X101 | ITCIEUR | INTRA-CELLULAR THERAPIES INC | $13.6M | 0.28% | 163,000 | Common | NONE |
| 00445A100 | — | ACELYRIN INC | $12.6M | 0.26% | 4,001,711 | Common | SOLE |
| 00288U106 | ABCL | ABCELLERA BIOLOGICS INC | $12.2M | 0.25% | 4,180,768 | Common | SOLE |
| H0036K147 | ADCT | ADC THERAPEUTICS SA | $11.9M | 0.24% | 5,968,451 | Common | NONE |
| 007002108 | TORCEUR | ADICET BIO INC | $11.0M | 0.23% | 11,447,140 | Common | SOLE |
| 69353Y103 | PMVP | PMV PHARMACEUTICALS INC | $9.8M | 0.20% | 6,475,291 | Common | SOLE |
| 913903100 | UHS | UNIVERSAL HLTH SVCS INC | $9.0M | 0.18% | 50,000 | CALL | NONE |
| 640979100 | NMRA | NEUMORA THERAPEUTICS INC. | $8.5M | 0.18% | 804,996 | Common | NONE |
| 746964105 | QTTB | Q32 BIO INC | $7.8M | 0.16% | 2,252,987 | Common | SOLE |
| 374163103 | GERN | GERON CORP | $7.7M | 0.16% | 2,168,000 | Common | NONE |
| 05338F306 | AVTX | AVALO THERAPEUTICS INC | $7.2M | 0.15% | 967,000 | Common | SOLE |
| 14147L108 | CRDF | CARDIFF ONCOLOGY INC | $6.7M | 0.14% | 1,538,462 | Common | SOLE |
| 717081103 | PFE | PFIZER INC | $6.6M | 0.14% | 250,000 | CALL | NONE |
| 80706P103 | SRRK | SCHOLAR ROCK HLDG CORP | $6.6M | 0.13% | 151,800 | Common | NONE |
| 457669307 | INSM | INSMED INC | $6.5M | 0.13% | 94,559 | Common | NONE |
| 29286M105 | — | ENGENE HOLDINGS INC | $6.1M | 0.13% | 920,339 | Common | SOLE |
| 45175G108 | — | IKENA ONCOLOGY INC | $5.8M | 0.12% | 3,539,358 | Common | SOLE |
| 45779A846 | NSPR | INSPIREMD INC | $5.6M | 0.12% | 2,133,405 | Common | SOLE |
| 68232V884 | TRAW | TRAWS PHARMA INC | $5.4M | 0.11% | 605,531 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE LABS INC | $5.3M | 0.11% | 921,959 | Common | SOLE |
| 98420X103 | ASNSUSD | X4 PHARMACEUTICALS INC | $5.2M | 0.11% | 7,133,515 | Common | SOLE |
| 055477103 | BCAX | BICARA THERAPEUTICS INC | $5.2M | 0.11% | 298,301 | Common | SOLE |
| 59935V107 | MIST | MILESTONE PHARMACEUTICALS IN | $4.7M | 0.10% | 2,000,000 | Common | SOLE |
| 760273102 | RPTX | REPARE THERAPEUTICS INC | $4.4M | 0.09% | 3,322,488 | Common | SOLE |
| 702712100 | — | PASSAGE BIO INC | $4.2M | 0.09% | 7,404,869 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $4.1M | 0.08% | 150,000 | CALL | NONE |
| 501147102 | KRYS | KRYSTAL BIOTECH INC | $3.7M | 0.08% | 23,500 | Common | NONE |
| 03980N107 | ARDT | ARDENT HEALTH PARTNERS INC | $3.5M | 0.07% | 206,000 | Common | NONE |
| 825704109 | SIBN | SI-BONE INC | $3.5M | 0.07% | 250,000 | CALL | NONE |
| 88033G407 | THC | TENET HEALTHCARE CORP | $3.2M | 0.06% | 25,000 | CALL | NONE |
| 16385C104 | — | CHEMOMAB THERAPEUTICS LTD | $3.2M | 0.06% | 1,741,273 | Common | SOLE |
| 15678C102 | CBLL | CERIBELL INC | $2.9M | 0.06% | 112,500 | Common | SOLE |
| 31189P102 | FATE | FATE THERAPEUTICS INC | $2.8M | 0.06% | 1,680,580 | Common | NONE |
| 713317105 | PEPG | PEPGEN INC | $2.5M | 0.05% | 653,016 | Common | NONE |
| 45783C200 | TIL | INSTIL BIO INC | $2.2M | 0.05% | 116,785 | Common | NONE |
| 65487U108 | NKTX | NKARTA INC | $2.0M | 0.04% | 821,400 | Common | NONE |
| 55083R104 | — | LYELL IMMUNOPHARMA INC | $2.0M | 0.04% | 3,103,623 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $1.9M | 0.04% | 78,500 | Common | NONE |
| 00973Y108 | AKRO | AKERO THERAPEUTICS INC | $1.8M | 0.04% | 66,000 | Common | NONE |
| 87583X109 | TNGX | TANGO THERAPEUTICS INC | $1.7M | 0.03% | 550,000 | Common | SOLE |
| 90042W100 | — | TURNSTONE BIOLOGICS CORP | $1.5M | 0.03% | 3,099,265 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $1.3M | 0.03% | 348,000 | Common | NONE |
| 09090D301 | — | BIOMX INC | $1.3M | 0.03% | 1,787,767 | Common | SOLE |
| 49372L209 | 2KZ0 | KEZAR LIFE SCIENCES INC | $1.3M | 0.03% | 192,700 | Common | NONE |
| 500946108 | KRRO | KORRO BIO INC | $1.2M | 0.03% | 32,400 | Common | NONE |
| 02157Q109 | ANRO | ALTO NEUROSCIENCE INC | $1.1M | 0.02% | 250,000 | Common | NONE |
| 65343E108 | NXTCEUR | NEXTCURE INC | $879,865 | 0.02% | 1,141,200 | Common | SOLE |
| 00847X104 | AGIO | AGIOS PHARMACEUTICALS INC | $877,362 | 0.02% | 26,700 | Common | NONE |
| 12529R107 | CCCC | C4 THERAPEUTICS INC | $540,000 | 0.01% | 150,000 | CALL | NONE |
| 28623U101 | — | ELEVATION ONCOLOGY INC | $529,561 | 0.01% | 941,275 | Common | SOLE |
| 00534A102 | IVVD | INVIVYD INC | $509,255 | 0.01% | 1,149,300 | Common | SOLE |
| G9845F208 | LSBCF | LAKESHORE BIOPHARMA CO LTD | $485,881 | 0.01% | 140,428 | Common | NONE |
| 98422E103 | XERS | XERIS BIOPHARMA HOLDINGS INC | $272,624 | 0.01% | 80,420 | Common | NONE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.