Q4 2025 · 13F-HR
SR ONE CAPITAL MANAGEMENT, LPholdings as filed
Filed 2026-02-12 · accession 0001193125-26-048808
$706.4M
Reported value
13
Positions
2025-12-31
Period end
The Brief · SR ONE CAPITAL MANAGEMENT, LP · Q4 2025
AI · grounded in 13F
SR ONE CAPITAL MANAGEMENT, LP established a new position in Ultragenyx Pharmaceutical Inc. RARE valued at $3.17M. The fund nearly doubled its stake in Oculis Holding AG OCS, increasing share count by 98.77%. It also accumulated more shares of Zenas BioPharma, Inc ZBIO and trimmed its holding in Mineralys Therapeutics Inc. MLYS by 26.02%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 98937L105 | ZBIO | Zenas BioPharma, Inc | $182.9M | 25.9% | 5,037,854 | Common | SOLE |
| 03940C100 | ACLXGBX | Arcellx, Inc. | $153.0M | 21.7% | 2,346,630 | Common | SOLE |
| H17182108 | CRSP | CRISPR Therapeutics AG | $106.9M | 15.1% | 2,038,763 | Common | SOLE |
| 25056L103 | DSGN | Design Therapeutics, Inc. | $61.2M | 8.67% | 6,526,476 | Common | SOLE |
| 603170101 | MLYS | Mineralys Therapeutics Inc. | $56.8M | 8.03% | 1,563,966 | Common | SOLE |
| 82835W108 | SPRY | ARS Pharmaceuticals, Inc. | $46.8M | 6.62% | 4,012,903 | Common | SOLE |
| 68622P109 | ORIC | ORIC Pharmaceuticals, Inc. | $37.8M | 5.34% | 4,514,929 | Common | SOLE |
| 022307102 | ALMS | Alumis Inc. | $19.1M | 2.71% | 1,959,896 | Common | SOLE |
| 687604108 | ORKA | Oruka Therapeutics, Inc | $13.0M | 1.85% | 430,330 | Common | SOLE |
| H5870P102 | OCS | Oculis Holding AG | $12.8M | 1.81% | 641,022 | Common | SOLE |
| 29286M105 | — | enGene Holdings Inc. | $6.8M | 0.96% | 747,750 | Common | SOLE |
| 65487U108 | NKTX | Nkarta, Inc. | $6.2M | 0.87% | 3,333,333 | Common | SOLE |
| 90400D108 | RARE | Ultragenyx Pharmaceutical Inc. | $3.2M | 0.45% | 137,753 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.