Q1 2024 · 13F-HR/A
Ikarian Capital, LLCholdings as filed
Filed 2024-05-17 · accession 0001420506-24-001013
$912.0M
Reported value
137
Positions
2024-03-31
Period end
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 501147102 | KRYS | KRYSTAL BIOTECH INC | $66.7M | 7.32% | 375,000 | PUT | SOLE |
| 78464A870 | XBI | SPDR SER TR | $66.4M | 7.28% | 700,000 | PUT | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $30.1M | 3.30% | 643,751 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $25.8M | 2.83% | 710,277 | Common | SOLE |
| 218352102 | CORT | CORCEPT THERAPEUTICS INC | $25.1M | 2.75% | 994,500 | PUT | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $24.7M | 2.71% | 396,600 | PUT | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $24.2M | 2.65% | 565,411 | Common | SOLE |
| 21833P301 | CRBP | CORBUS PHARMACEUTICALS HLDGS | $21.9M | 2.41% | 559,271 | Common | SOLE |
| 046353108 | AZNN | ASTRAZENECA PLC | $20.9M | 2.30% | 309,200 | CALL | SOLE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $20.4M | 2.24% | 136,700 | PUT | SOLE |
| 803607100 | SRPT | SAREPTA THERAPEUTICS INC | $19.7M | 2.16% | 152,278 | Common | SOLE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $18.1M | 1.98% | 120,800 | CALL | SOLE |
| 501147102 | KRYS | KRYSTAL BIOTECH INC | $17.8M | 1.95% | 100,000 | CALL | SOLE |
| 031162100 | AMGN | AMGEN INC | $17.1M | 1.87% | 60,000 | CALL | SOLE |
| 92686J106 | VKTX | VIKING THERAPEUTICS INC | $16.4M | 1.80% | 200,000 | PUT | SOLE |
| 09077A106 | BMEA | BIOMEA FUSION INC | $16.1M | 1.77% | 1,077,600 | CALL | SOLE |
| 803607100 | SRPT | SAREPTA THERAPEUTICS INC | $15.0M | 1.65% | 116,100 | CALL | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $14.1M | 1.54% | 300,400 | PUT | SOLE |
| 558868105 | MDGL | MADRIGAL PHARMACEUTICALS INC | $13.7M | 1.50% | 51,400 | PUT | SOLE |
| 30233G209 | EYPT | EYEPOINT PHARMACEUTICALS INC | $13.6M | 1.49% | 658,200 | PUT | SOLE |
| G1110E107 | BHVN | BIOHAVEN LTD | $12.2M | 1.34% | 223,700 | CALL | SOLE |
| 10806X102 | BBIO | BRIDGEBIO PHARMA INC | $12.0M | 1.32% | 389,400 | CALL | SOLE |
| 008064107 | — | AEROVATE THERAPEUTICS INC | $10.9M | 1.19% | 367,965 | Common | SOLE |
| 516544103 | LNTH | LANTHEUS HLDGS INC | $10.6M | 1.16% | 170,000 | CALL | SOLE |
| 00445A100 | — | ACELYRIN INC | $10.6M | 1.16% | 1,564,340 | Common | SOLE |
| 02083G100 | NVLSEUR | ALPINE IMMUNE SCIENCES INC | $10.4M | 1.14% | 261,365 | Common | SOLE |
| 74006W207 | PRAX | PRAXIS PRECISION MEDICINES I | $10.3M | 1.13% | 168,388 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $10.2M | 1.12% | 145,147 | Common | SOLE |
| 03589W102 | ANNX | ANNEXON INC | $10.1M | 1.10% | 1,405,000 | Common | SOLE |
| 015271109 | ARE | ALEXANDRIA REAL ESTATE EQ IN | $9.4M | 1.04% | 73,300 | PUT | SOLE |
| 457669307 | INSM | INSMED INC | $9.4M | 1.03% | 347,200 | CALL | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $8.9M | 0.98% | 276,925 | Common | SOLE |
| 10806X102 | BBIO | BRIDGEBIO PHARMA INC | $8.7M | 0.96% | 282,013 | Common | SOLE |
| 14888U101 | CPRX | CATALYST PHARMACEUTICALS INC | $8.3M | 0.91% | 518,386 | Common | SOLE |
| 35104E100 | FDMT | 4D MOLECULAR THERAPEUTICS IN | $8.2M | 0.90% | 257,600 | CALL | SOLE |
| 35104E100 | FDMT | 4D MOLECULAR THERAPEUTICS IN | $8.2M | 0.90% | 257,600 | PUT | SOLE |
| 77313F106 | RCKT | ROCKET PHARMACEUTICALS INC | $8.0M | 0.88% | 297,096 | Common | SOLE |
| 61559X104 | MLTX | MOONLAKE IMMUNOTHERAPEUTICS | $7.9M | 0.87% | 158,000 | PUT | SOLE |
| 556099109 | MGNX | MACROGENICS INC | $7.7M | 0.84% | 523,500 | CALL | SOLE |
| 02043Q107 | ALNY | ALNYLAM PHARMACEUTICALS INC | $7.7M | 0.84% | 51,541 | Common | SOLE |
| 670703107 | NUVL | NUVALENT INC | $7.6M | 0.84% | 101,601 | Common | SOLE |
| 747324101 | PYXS | PYXIS ONCOLOGY INC | $7.1M | 0.78% | 1,662,408 | Common | SOLE |
| 218352102 | CORT | CORCEPT THERAPEUTICS INC | $7.0M | 0.77% | 279,500 | CALL | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $7.0M | 0.77% | 100,000 | PUT | SOLE |
| 55234L105 | LYRAGBP | LYRA THERAPEUTICS INC | $6.6M | 0.72% | 1,056,829 | Common | SOLE |
| 00289Y206 | ABEO | ABEONA THERAPEUTICS INC | $6.4M | 0.71% | 888,593 | Common | SOLE |
| 80706P103 | SRRK | SCHOLAR ROCK HLDG CORP | $6.4M | 0.71% | 362,300 | CALL | SOLE |
| 925050106 | VRNA | VERONA PHARMA PLC | $6.0M | 0.66% | 375,310 | Common | SOLE |
| 03753U106 | APLSUSD | APELLIS PHARMACEUTICALS INC | $5.9M | 0.64% | 100,000 | PUT | SOLE |
| 03969K108 | ARQT | ARCUTIS BIOTHERAPEUTICS INC | $5.8M | 0.64% | 589,642 | Common | SOLE |
| 23256X100 | — | CYBIN INC | $5.8M | 0.63% | 13,953,488 | Common | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $5.6M | 0.62% | 400,000 | CALL | SOLE |
| 15713L109 | CRVO | CERVOMED INC | $5.5M | 0.61% | 237,345 | Common | SOLE |
| 80706P103 | SRRK | SCHOLAR ROCK HLDG CORP | $5.2M | 0.57% | 291,701 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $5.2M | 0.57% | 120,400 | PUT | SOLE |
| 56854Q200 | MRNS* | MARINUS PHARMACEUTICALS INC | $4.9M | 0.53% | 537,925 | Common | SOLE |
| 556099109 | MGNX | MACROGENICS INC | $4.7M | 0.51% | 318,167 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $4.6M | 0.51% | 107,187 | Common | SOLE |
| 67080M103 | NRIX | NURIX THERAPEUTICS INC | $4.4M | 0.48% | 300,000 | Common | SOLE |
| 30233G209 | EYPT | EYEPOINT PHARMACEUTICALS INC | $4.3M | 0.47% | 206,500 | CALL | SOLE |
| 89157D105 | TRML | TOURMALINE BIO INC | $4.1M | 0.45% | 179,200 | CALL | SOLE |
| 02083G100 | NVLSEUR | ALPINE IMMUNE SCIENCES INC | $4.1M | 0.45% | 103,000 | CALL | SOLE |
| Y95308105 | WVE | WAVE LIFE SCIENCES LTD | $3.6M | 0.40% | 590,088 | Common | SOLE |
| 87650L103 | TARS | TARSUS PHARMACEUTICALS INC | $3.6M | 0.40% | 100,000 | CALL | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $3.5M | 0.38% | 81,100 | CALL | SOLE |
| 12674W109 | CABA | CABALETTA BIO INC | $3.4M | 0.37% | 200,000 | PUT | SOLE |
| 517125100 | LRMR | LARIMAR THERAPEUTICS INC | $3.3M | 0.36% | 438,528 | Common | SOLE |
| 92790C104 | VRDN | VIRIDIAN THERAPEUTICS INC | $3.1M | 0.34% | 178,900 | PUT | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $3.1M | 0.34% | 49,600 | CALL | SOLE |
| 471871202 | JSPR | JASPER THERAPEUTICS INC | $3.1M | 0.34% | 105,175 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $3.0M | 0.33% | 1,060,100 | CALL | SOLE |
| 03615A108 | ANVS | ANNOVIS BIO INC | $3.0M | 0.33% | 251,900 | PUT | SOLE |
| 00791X100 | — | AEON BIOPHARMA INC | $3.0M | 0.33% | 257,977 | Common | SOLE |
| 03615A108 | ANVS | ANNOVIS BIO INC | $3.0M | 0.33% | 250,000 | CALL | SOLE |
| 60255C885 | BRD1EUR | MIND MEDICINE MINDMED INC | $2.8M | 0.31% | 297,481 | Common | SOLE |
| 92332V107 | VTYXUSD | VENTYX BIOSCIENCES INC | $2.8M | 0.31% | 507,647 | Common | SOLE |
| 56854Q200 | MRNS* | MARINUS PHARMACEUTICALS INC | $2.7M | 0.30% | 303,200 | CALL | SOLE |
| 50015M109 | KOD | KODIAK SCIENCES INC | $2.5M | 0.27% | 476,586 | Common | SOLE |
| 89157D105 | TRML | TOURMALINE BIO INC | $2.5M | 0.27% | 108,483 | Common | SOLE |
| N90064101 | QURE | UNIQURE NV | $2.4M | 0.27% | 469,133 | Common | SOLE |
| 451033708 | IBIO | IBIO INC | $2.4M | 0.27% | 600,000 | Common | SOLE |
| 67080N101 | NUVB | NUVATION BIO INC | $2.3M | 0.25% | 633,282 | Common | SOLE |
| 786700104 | SGMT | SAGIMET BIOSCIENCES INC | $2.2M | 0.25% | 412,565 | Common | SOLE |
| 75382E109 | — | RAPT THERAPEUTICS INC | $2.2M | 0.24% | 246,200 | PUT | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $2.2M | 0.24% | 153,700 | PUT | SOLE |
| 4525EP101 | VTLUSD | IMMUNIC INC | $2.1M | 0.23% | 1,612,378 | Common | SOLE |
| 03753U106 | APLSUSD | APELLIS PHARMACEUTICALS INC | $2.1M | 0.23% | 35,092 | Common | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $2.0M | 0.22% | 140,687 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $1.9M | 0.21% | 70,900 | PUT | SOLE |
| 56854Q200 | MRNS* | MARINUS PHARMACEUTICALS INC | $1.9M | 0.21% | 212,200 | PUT | SOLE |
| 52635N103 | LENZ | LENZ THERAPEUTICS INC | $1.9M | 0.21% | 85,000 | Common | SOLE |
| 00449L102 | 698 | ACHILLES THERAPEUTICS PLC | $1.8M | 0.20% | 1,443,181 | Common | SOLE |
| 92915B106 | VYGR | VOYAGER THERAPEUTICS INC | $1.7M | 0.18% | 180,857 | Common | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $1.6M | 0.17% | 25,372 | Common | SOLE |
| 09077A106 | BMEA | BIOMEA FUSION INC | $1.5M | 0.17% | 103,000 | PUT | SOLE |
| 457669307 | INSM | INSMED INC | $1.4M | 0.15% | 51,335 | Common | SOLE |
| 75382E109 | — | RAPT THERAPEUTICS INC | $1.4M | 0.15% | 154,625 | Common | SOLE |
| 46565G104 | 5E7 | ITEOS THERAPEUTICS INC | $1.4M | 0.15% | 101,325 | Common | SOLE |
| 74006W207 | PRAX | PRAXIS PRECISION MEDICINES I | $1.3M | 0.15% | 21,800 | CALL | SOLE |
| 01671P100 | ALLKGUSD | ALLAKOS INC | $1.2M | 0.13% | 932,675 | Common | SOLE |
| N71542109 | PRQR | PROQR THRAPEUTICS N V | $1.1M | 0.12% | 483,583 | Common | SOLE |
| N44821101 | IFRX | INFLARX NV | $1.1M | 0.12% | 704,987 | Common | SOLE |
| 00509G209 | ABOS | ACUMEN PHARMACEUTICALS INC | $1.1M | 0.12% | 266,435 | Common | SOLE |
| G76279101 | ROIV | ROIVANT SCIENCES LTD | $1.1M | 0.12% | 100,609 | Common | SOLE |
| 05338F306 | AVTX | AVALO THERAPEUTICS INC | $1.0M | 0.11% | 46,648 | Common | SOLE |
| 05455M100 | — | AVROBIO INC | $965,198 | 0.11% | 754,061 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $941,321 | 0.10% | 331,451 | Common | SOLE |
| 59935V107 | MIST | MILESTONE PHARMACEUTICALS IN | $834,174 | 0.09% | 466,019 | Common | SOLE |
| 74365U107 | TARA | PROTARA THERAPEUTICS INC | $812,830 | 0.09% | 202,701 | Common | SOLE |
| 49372L100 | — | KEZAR LIFE SCIENCES INC | $783,484 | 0.09% | 868,992 | Common | SOLE |
| 75382E109 | — | RAPT THERAPEUTICS INC | $783,056 | 0.09% | 87,200 | CALL | SOLE |
| 28623U101 | — | ELEVATION ONCOLOGY INC | $759,697 | 0.08% | 148,089 | Common | SOLE |
| B6S7WD106 | NYXH | NYXOAH S A | $683,929 | 0.07% | 50,699 | Common | SOLE |
| 92536C103 | VERUEUR | VERU INC | $662,563 | 0.07% | 946,382 | Common | SOLE |
| 48576U106 | KPTIEUR | KARYOPHARM THERAPEUTICS INC | $618,126 | 0.07% | 409,355 | Common | SOLE |
| 880881107 | 430 | TERNS PHARMACEUTICALS INC | $580,540 | 0.06% | 88,497 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $529,376 | 0.06% | 186,400 | PUT | SOLE |
| N44445109 | IMTX | IMMATICS N.V | $519,351 | 0.06% | 49,415 | Common | SOLE |
| 38000Q102 | GLYCEUR | GLYCOMIMETICS INC | $518,400 | 0.06% | 172,800 | CALL | SOLE |
| 38000Q102 | GLYCEUR | GLYCOMIMETICS INC | $518,400 | 0.06% | 172,800 | PUT | SOLE |
| 00289Y206 | ABEO | ABEONA THERAPEUTICS INC | $489,375 | 0.05% | 67,500 | CALL | SOLE |
| 034569103 | ANEB | ANEBULO PHARMACEUTICALS INC | $453,064 | 0.05% | 157,862 | Common | SOLE |
| 87978U108 | OVASUSD | TEMPEST THERAPEUTICS INC | $412,895 | 0.05% | 105,600 | Common | SOLE |
| 22663K107 | CRNX | CRINETICS PHARMACEUTICALS IN | $407,247 | 0.04% | 8,700 | CALL | SOLE |
| 746964105 | QTTB | Q32 BIO INC | $380,588 | 0.04% | 22,335 | Common | SOLE |
| 43906K100 | HOOKGBP | HOOKIPA PHARMA INC | $377,913 | 0.04% | 530,776 | Common | SOLE |
| 75955J402 | RLMD | RELMADA THERAPEUTICS INC | $187,717 | 0.02% | 40,369 | Common | SOLE |
| 16385C104 | — | CHEMOMAB THERAPEUTICS LTD | $166,232 | 0.02% | 213,392 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $92,017 | 0.01% | 6,816 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $85,720 | 0.01% | 2,000 | CALL | SOLE |
| 10501E201 | BCLIEUR | BRAINSTORM CELL THERAPEUTICS | $50,960 | 0.01% | 90,242 | Common | SOLE |
| 87166L209 | SYBX | SYNLOGIC INC | $36,602 | 0.00% | 20,448 | Common | SOLE |
| 30233G209 | EYPT | EYEPOINT PHARMACEUTICALS INC | $21,642 | 0.00% | 1,047 | Common | SOLE |
| 31773D200 | FNCHQ | FINCH THERAPEUTICS GROUP INC | $18,126 | 0.00% | 6,892 | Common | SOLE |
| 90240B106 | TYRA | TYRA BIOSCIENCES INC | $8,216 | 0.00% | 501 | Common | SOLE |
| 04522R200 | — | ASLAN PHARMACEUTICALS LTD | $6,273 | 0.00% | 35,420 | Common | SOLE |
| 54300N103 | — | LONGBOARD PHARMACEUTICALS IN | $5,098 | 0.00% | 236 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.