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Caligan Partners LP

Q4 2025 · 13F-HR

Caligan Partners LPholdings as filed

Filed 2026-02-17 · accession 0001420506-26-000584

$1.21B
Reported value
24
Positions
2025-12-31
Period end
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The Brief · Caligan Partners LP · Q4 2025

AI · grounded in 13F

Caligan Partners LP established a new position in PCVX valued at $78.66M. The fund also opened a new position in TNGX for $33.05M and increased its stake in XENE by 147.29%. On the selling side, the fund closed its positions in EOLS and 2GH, resulting in reductions of $25.41M and $20.43M respectively.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
53635D202LQDALIQUIDIA CORPORATION$280.0M23.1%8,118,892CommonSOLE
00370M103ABVXABIVAX SA$195.8M16.1%1,451,924CommonSOLE
76155X100RVMDREVOLUTION MEDICINES INC$102.3M8.42%1,283,900CommonSOLE
603170101MLYSMINERALYS THERAPEUTICS INC$100.6M8.28%2,772,654CommonSOLE
603170101MLYSMINERALYS THERAPEUTICS INC$83.4M6.87%2,298,400PUTSOLE
92243G108PCVXVAXCYTE INC$78.7M6.48%1,704,815CommonSOLE
30161Q104EXELEXELIXIS INC$68.1M5.60%1,553,262CommonSOLE
000899104ADMAADMA BIOLOGICS INC$54.9M4.52%3,012,508CommonSOLE
87583X109TNGXTANGO THERAPEUTICS INC$33.0M2.72%3,729,895CommonSOLE
45720N103INBXINHIBRX BIOSCIENCES INC$25.6M2.10%323,565CommonSOLE
90240B106TYRATYRA BIOSCIENCES INC$24.8M2.04%944,257CommonSOLE
98420N105XENEXENON PHARMACEUTICALS INC$24.6M2.03%549,700PUTSOLE
98420N105XENEXENON PHARMACEUTICALS INC$24.6M2.03%549,665CommonSOLE
578784100MAZEMAZE THERAPEUTICS INC$22.8M1.88%550,191CommonSOLE
75382E208RAPTRAPT THERAPEUTICS INC$21.8M1.80%644,400CommonSOLE
05338F306AVTXAVALO THERAPEUTICS INC$16.0M1.32%881,533CommonSOLE
035255108ANIKANIKA THERAPEUTICS INC$13.8M1.14%1,435,130CommonSOLE
45720N103INBXINHIBRX BIOSCIENCES INC$11.8M0.98%150,000CALLSOLE
929033207VORVOR BIOPHARMA INC$10.0M0.82%925,067CommonSOLE
46124U107IVAINVENTIVA SA$9.3M0.77%2,000,000CommonSOLE
92511W207VRCAVERRICA PHARMACEUTICALS INC$7.7M0.63%923,910CommonSOLE
00847X104AGIOAGIOS PHARMACEUTICALS INC$2.4M0.20%90,000CALLSOLE
85209E208SPRBSPRUCE BIOSCIENCES INC$1.8M0.15%20,514CommonSOLE
28617K101ELDNELEDON PHARMACEUTICALS INC$839,5270.07%555,978CommonSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.