Q3 2025 · 13F-HR
Opaleye Management Inc.holdings as filed
Filed 2025-11-14 · accession 0001493152-25-023429
$707.3M
Reported value
43
Positions
2025-09-30
Period end
The Brief · Opaleye Management Inc. · Q3 2025
AI · grounded in 13F
Opaleye Management Inc. established a new position in Harrow Health Inc. HROW valued at $188.1M. The fund also initiated new stakes in Eton Pharmaceuticals Inc. ETON for $62.1M and Liquidia Corporation LQDA for $59.5M. Other new additions include Rhythm Pharmaceuticals Inc. RYTM and Immunome Inc. IMNM.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 415858109 | HROW | HARROW HEALTH INC | $188.1M | 26.6% | 3,905,000 | Common | SOLE |
| 29772L108 | ETON | ETON PHARMACEUTICALS INC | $62.1M | 8.79% | 2,860,000 | Common | SOLE |
| 53635D202 | LQDA | LIQUIDIA CORPORATION | $59.5M | 8.41% | 2,615,000 | Common | SOLE |
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $46.6M | 6.59% | 461,700 | Common | SOLE |
| 45257U108 | IMNM | IMMUNOME INC | $37.3M | 5.27% | 3,185,000 | Common | SOLE |
| 80303D305 | SNWV | SANUWAVE HEALTH INC | $36.7M | 5.19% | 980,000 | Common | SOLE |
| 192005106 | CDXS | CODEXIS INC | $31.2M | 4.41% | 12,795,000 | Common | SOLE |
| 88322Q108 | TGTX | TG THERAPEUTICS INC | $19.3M | 2.73% | 535,000 | Common | SOLE |
| 67576A100 | OCUL | OCULAR THERAPEUTIX INC | $18.6M | 2.64% | 1,595,000 | Common | SOLE |
| 156944100 | CGON | CG ONCOLOGY INC | $16.5M | 2.33% | 410,000 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $16.0M | 2.27% | 682,017 | Common | SOLE |
| 03770N101 | APGE | APOGEE THERAPEUTICS INC | $14.4M | 2.04% | 363,257 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $13.5M | 1.91% | 450,000 | Common | SOLE |
| 254604101 | IRON | DISC MEDICINE INC | $12.8M | 1.81% | 193,773 | Common | SOLE |
| 803607100 | SRPT | SAREPTA THERAPEUTICS INC | $11.3M | 1.59% | 585,000 | Common | SOLE |
| 517125100 | LRMR | LARIMAR THERAPEUTICS INC | $10.6M | 1.49% | 3,720,867 | Common | SOLE |
| 98419J206 | XOMA | XOMA CORP DEL | $9.8M | 1.39% | 255,087 | Common | SOLE |
| 76200L309 | RZLT | REZOLUTE INC | $8.5M | 1.20% | 903,442 | Common | SOLE |
| 04335A105 | ARVN | ARVINAS INC | $8.4M | 1.19% | 987,818 | Common | SOLE |
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $8.1M | 1.15% | 500,000 | Common | SOLE |
| 03589W102 | ANNX | ANNEXON INC | $7.9M | 1.12% | 2,600,000 | Common | SOLE |
| 38341P102 | GOSS | GOSSAMER BIO INC | $7.2M | 1.01% | 2,725,000 | Common | SOLE |
| 74366E102 | PTGX | PROTAGONIST THERAPEUTICS INC | $7.0M | 0.99% | 105,000 | Common | SOLE |
| 48115J109 | DERM | JOURNEY MEDICAL CORP | $6.9M | 0.98% | 971,064 | Common | SOLE |
| M8694L137 | SLGL | SOL GEL TECHNOLOGIES | $6.0M | 0.84% | 204,835 | Common | SOLE |
| 74365A309 | PLX | PROTALIX BIOTHERAPEUTICS INC | $5.7M | 0.81% | 2,580,556 | Common | SOLE |
| 89455T109 | TMCI | TREACE MEDICAL CONCEPTS INC | $4.7M | 0.67% | 702,245 | Common | SOLE |
| 76155X100 | RVMD | REVOLUTION MEDICINES INC | $4.7M | 0.66% | 100,000 | Common | SOLE |
| 48576UAA4 | KPTI 3 10/15/25 | KARYOPHARM THERAPEUTICS INC | $4.6M | 0.65% | 6,000,000 | Common | SOLE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $4.4M | 0.63% | 253,000 | Common | SOLE |
| 89532M101 | TRVI | TREVI THERAPEUTICS INC | $3.6M | 0.50% | 390,000 | Common | SOLE |
| H0036K147 | ADCT | ADC Therapeutics SA | $2.7M | 0.39% | 682,529 | Common | SOLE |
| 022307102 | ALMS | ALUMIS INC | $2.7M | 0.38% | 665,000 | Common | SOLE |
| 12674W109 | CABA | CABALETTA BIO INC | $1.9M | 0.27% | 808,882 | Common | SOLE |
| 67577R102 | IRD | OPUS GENETICS INC | $1.8M | 0.26% | 1,100,000 | Common | SOLE |
| 98985Y108 | ZYME | ZYMEWORKS INC | $1.7M | 0.24% | 100,000 | Common | SOLE |
| 00773J202 | SYRE | SPYRE THERAPEUTICS INC | $1.1M | 0.15% | 65,000 | Common | SOLE |
| 766559702 | RIGL | RIGEL PHARMACEUTICALS | $1.1M | 0.15% | 37,787 | Common | SOLE |
| 02074J501 | ACOG | ALPHA COGNITION INC | $749,574 | 0.11% | 115,142 | Common | SOLE |
| 98943L107 | ZNTL | ZENTALIS PHARMACEUTICALS INC | $477,991 | 0.07% | 316,550 | Common | SOLE |
| 713317105 | PEPG | PEPGEN INC | $346,500 | 0.05% | 75,000 | Common | SOLE |
| 451033708 | IBIO | IBIO INC | $310,425 | 0.04% | 375,000 | Common | SOLE |
| 00534B100 | ADGM | ADAGIO MED HLDGS INC | $214,508 | 0.03% | 110,571 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.