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PERCEPTIVE ADVISORS LLC

Q2 2025 · 13F-HR

PERCEPTIVE ADVISORS LLCholdings as filed

Filed 2025-08-14 · accession 0001012975-25-000446

$2.70B
Reported value
85
Positions
2025-06-30
Period end
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The Brief · PERCEPTIVE ADVISORS LLC · Q2 2025

AI · grounded in 13F

PERCEPTIVE ADVISORS LLC established a new position in VRNA valued at $520.9M. The fund also initiated new stakes in ASNDUSD for $166.4M and ACLXGBX for $163.2M. Additional new positions include RYTM at $152.8M and NUVL at $104.9M. Total assets under management stand at $2.7B across 84 positions.

Holdings as filed

CUSIPTickerIssuerValue% port.SharesClassVoting
925050106VRNAVERONA PHARMA PLC$520.9M19.3%5,507,591CommonSOLE
04351P101ASNDUSDASCENDIS PHARMA A/S$166.4M6.17%963,886CommonSOLE
03940C100ACLXGBXARCELLX INC$163.2M6.05%2,478,000CommonSOLE
76243J105RYTMRHYTHM PHARMACEUTICALS INC$152.8M5.67%2,418,299CommonSOLE
670703107NUVLNUVALENT INC$104.9M3.89%1,375,180CommonSOLE
228903100AORTARTIVION INC$86.9M3.22%2,793,703CommonSOLE
G59665102MGTXMEIRAGTX HLDGS PLC$82.2M3.05%12,626,103CommonSOLE
457669307INSMINSMED INC$65.4M2.43%650,252CommonSOLE
28036F105EWTXEDGEWISE THERAPEUTICS INC$60.8M2.26%4,639,949CommonSOLE
74366E102PTGXPROTAGONIST THERAPEUTICS INC$59.4M2.20%1,074,448CommonSOLE
83422E204SLDBSOLID BIOSCIENCES INC$58.0M2.15%11,906,646CommonSOLE
03770N101APGEAPOGEE THERAPEUTICS INC$51.3M1.90%1,182,148CommonSOLE
03237H101AMLXAMYLYX PHARMACEUTICALS INC$50.7M1.88%7,902,365CommonSOLE
N44445109IMTXIMMATICS N.V$50.5M1.87%9,383,456CommonSOLE
00973Y108AKROAKERO THERAPEUTICS INC$48.9M1.81%915,887CommonSOLE
68170A108OMDAOMADA HEALTH INC$44.4M1.65%2,426,330CommonSOLE
03152W109AM6AMICUS THERAPEUTICS INC$42.5M1.57%7,412,830CommonSOLE
G76279101ROIVROIVANT SCIENCES LTD$37.5M1.39%3,331,465CommonSOLE
N5749R1002GHMERUS N V$37.3M1.38%708,176CommonSOLE
834203309SLNOSOLENO THERAPEUTICS INC$36.1M1.34%430,439CommonSOLE
04635X102CATBUSDASTRIA THERAPEUTICS INC$34.8M1.29%6,485,420CommonSOLE
45258J102IMVTIMMUNOVANT INC$34.2M1.27%2,137,890CommonSOLE
64125C109NBIXNEUROCRINE BIOSCIENCES INC$32.1M1.19%255,050CommonSOLE
74006W207PRAXPRAXIS PRECISION MEDICINES I$31.7M1.17%752,921CommonSOLE
101137107BSXBOSTON SCIENTIFIC CORP$30.1M1.11%280,000CommonSOLE
142152107CAICARIS LIFE SCIENCES INC$29.3M1.09%1,098,163CommonSOLE
78464A870XBISPDR SERIES TRUST$24.9M0.92%300,000PUTSOLE
46120E602ISRGINTUITIVE SURGICAL INC$24.5M0.91%45,119CommonSOLE
000899104ADMAADMA BIOLOGICS INC$23.7M0.88%1,303,468CommonSOLE
08659B102BBNXBETA BIONICS INC$23.2M0.86%1,593,608CommonSOLE
00773J202SYRESPYRE THERAPEUTICS INC$22.9M0.85%1,529,445CommonSOLE
30052C107EOLSEVOLUS INC$22.8M0.85%2,474,843CommonSOLE
15102K100CELCCELCUITY INC$21.8M0.81%1,633,208CommonSOLE
26818M108DYNDYNE THERAPEUTICS INC$21.4M0.79%2,247,390CommonSOLE
829401108SIONSIONNA THERAPEUTICS INC$21.1M0.78%1,216,045CommonSOLE
05464T104AXSMAXSOME THERAPEUTICS INC$20.7M0.77%198,534CommonSOLE
759916109RGENREPLIGEN CORP$20.6M0.77%166,000CommonSOLE
45784P101PODDINSULET CORP$19.0M0.70%60,387CommonSOLE
690145206OMOUTSET MED INC$16.0M0.59%833,333CommonSOLE
98985Y108ZYMEZYMEWORKS INC$16.0M0.59%1,275,274CommonSOLE
23284F105CTMXCYTOMX THERAPEUTICS INC$15.9M0.59%6,993,646CommonSOLE
01438T106ALDXALDEYRA THERAPEUTICS INC$15.5M0.58%4,051,631CommonSOLE
159864107CRLCHARLES RIV LABS INTL INC$15.2M0.56%100,000CommonSOLE
152309100CNTACENTESSA PHARMACEUTICALS PLC$15.1M0.56%1,146,935CommonSOLE
45720N103INBXINHIBRX BIOSCIENCES INC$14.0M0.52%977,892CommonSOLE
00534B100ADGMADAGIO MED HLDGS INC$12.8M0.48%9,876,576CommonSOLE
67080M103NRIXNURIX THERAPEUTICS INC$12.5M0.46%1,096,985CommonSOLE
89422G107TVTXTRAVERE THERAPEUTICS INC$12.3M0.46%834,252CommonSOLE
68572M106OBIOORCHESTRA BIOMED HLDGS INC$12.3M0.46%4,592,556CommonSOLE
10919W405DRUGBRIGHT MINDS BIOSCIENCES INC$11.0M0.41%420,690CommonSOLE
45719W205IKTINHIBIKASE THERAPEUTICS INC$10.6M0.39%5,432,293CommonSOLE
92686J106VKTXVIKING THERAPEUTICS INC$10.1M0.37%380,700CommonSOLE
90400D108RAREULTRAGENYX PHARMACEUTICAL IN$9.8M0.36%270,000CommonSOLE
501575104KYMRKYMERA THERAPEUTICS INC$9.2M0.34%210,106CommonSOLE
63909J108NAUTNAUTILUS BIOTECHNOLOGY INC$9.1M0.34%12,594,211CommonSOLE
70975L107PENPENUMBRA INC$8.4M0.31%32,797CommonSOLE
G2545C104CBIOCRESCENT BIOPHARMA INC.$7.3M0.27%453,686CommonSOLE
03843E104AQSTAQUESTIVE THERAPEUTICS INC$7.3M0.27%2,190,420CommonSOLE
47103J105JANXJANUX THERAPEUTICS INC$6.8M0.25%292,686CommonSOLE
03675P102AVRANTERIS TECHNOLOGIES GLOBAL$6.5M0.24%1,705,130CommonSOLE
14070B309CAPRCAPRICOR THERAPEUTICS INC$6.5M0.24%650,000PUTSOLE
98420N105XENEXENON PHARMACEUTICALS INC$6.3M0.23%200,791CommonSOLE
92790C104VRDNVIRIDIAN THERAPEUTICS INC$6.3M0.23%447,507CommonSOLE
221015100CRVSCORVUS PHARMACEUTICALS INC$5.8M0.21%1,438,595CommonSOLE
81734D104SEPNSEPTERNA INC$5.7M0.21%541,450CommonSOLE
379577208GMEDGLOBUS MED INC$5.2M0.19%88,500CommonSOLE
29415J106NVNOENVVENO MEDICAL CORPORATION$5.1M0.19%1,284,966CommonSOLE
G4444H101BBOTHELIX ACQUISITION CORP II$4.2M0.16%398,000CommonSOLE
67577R102IRDOPUS GENETICS INC$4.1M0.15%4,325,000CommonSOLE
21217B100CTNMCONTINEUM THERAPEUTICS INC$2.8M0.10%699,486CommonSOLE
55234L204LYRALYRA THERAPEUTICS INC$2.3M0.08%255,150CommonSOLE
810648105SCPHSCPHARMACEUTICALS INC$1.9M0.07%500,000CommonSOLE
04746L104ATHIRA PHARMA INC$1.6M0.06%5,402,964CommonSOLE
75382E208RAPTRAPT THERAPEUTICS INC$1.5M0.05%183,890CommonSOLE
896438504TRIBTRINITY BIOTECH PLC$1.2M0.04%1,790,000CommonSOLE
14070B309CAPRCAPRICOR THERAPEUTICS INC$993,0000.04%100,000CALLSOLE
34962G208FBRXFORTE BIOSCIENCES INC$881,7230.03%68,192CommonSOLE
05338F306AVTXAVALO THERAPEUTICS INC$696,9380.03%139,667CommonSOLE
09075X108BDSXBIODESIX INC$613,0340.02%2,173,880CommonSOLE
52886X107LXEOLEXEO THERAPEUTICS INC$562,1370.02%139,835CommonSOLE
03837C106APYXAPYX MEDICAL CORPORATION$337,5000.01%150,000CommonSOLE
483119202KALAEURKALA BIO INC$262,8810.01%55,227CommonSOLE
293602504ENSCENSYSCE BIOSCIENCES INC$193,2650.01%86,666CommonSOLE
76155X118RVMDWREVOLUTION MEDICINES INC$65,6750.00%250,000CommonSOLE
86889P117SRZNWSURROZEN INC$3,0170.00%166,666CommonSOLE

Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.