Q3 2025 · 13F-HR
PERCEPTIVE ADVISORS LLCholdings as filed
Filed 2025-11-14 · accession 0001012975-25-000762
$3.46B
Reported value
92
Positions
2025-09-30
Period end
The Brief · PERCEPTIVE ADVISORS LLC · Q3 2025
AI · grounded in 13F
Perceptive Advisors LLC established a new position in Rhythm Pharmaceuticals Inc RYTM valued at $288.4M. The fund also initiated new stakes in Ascendis Pharma A/S ASNDUSD for $216.4M and Arcellx Inc ACLXGBX for $202.7M. Other new additions include Celcuity Inc CELC and Nuvalent Inc NUVL. The fund ended the period with 92 positions and total AUM of $3.46B.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 76243J105 | RYTM | RHYTHM PHARMACEUTICALS INC | $288.4M | 8.33% | 419,104,969 | Common | SOLE |
| 04351P101 | ASNDUSD | ASCENDIS PHARMA A/S | $216.4M | 6.25% | 1,088,501 | Common | SOLE |
| 03940C100 | ACLXGBX | ARCELLX INC | $202.7M | 5.85% | 2,468,353 | Common | SOLE |
| 15102K100 | CELC | CELCUITY INC | $146.0M | 4.22% | 2,956,319 | Common | SOLE |
| 670703107 | NUVL | NUVALENT INC | $135.1M | 3.90% | 1,562,336 | Common | SOLE |
| N5749R100 | 2GH | MERUS N V | $127.4M | 3.68% | 1,353,093 | Common | SOLE |
| 03237H101 | AMLX | AMYLYX PHARMACEUTICALS INC | $121.7M | 3.51% | 8,952,365 | Common | SOLE |
| G76279101 | ROIV | ROIVANT SCIENCES LTD | $111.5M | 3.22% | 7,368,461 | Common | SOLE |
| G59665102 | MGTX | MEIRAGTX HLDGS PLC | $103.8M | 3.00% | 12,626,103 | Common | SOLE |
| 457669307 | INSM | INSMED INC | $101.1M | 2.92% | 702,130 | Common | SOLE |
| 89422G107 | TVTX | TRAVERE THERAPEUTICS INC | $90.7M | 2.62% | 3,794,615 | Common | SOLE |
| 228903100 | AORT | ARTIVION INC | $85.5M | 2.47% | 2,020,000 | Common | SOLE |
| 74006W207 | PRAX | PRAXIS PRECISION MEDICINES I | $82.9M | 2.39% | 1,564,554 | Common | SOLE |
| N44445109 | IMTX | IMMATICS N.V | $79.9M | 2.31% | 9,383,456 | Common | SOLE |
| 152309100 | CNTA | CENTESSA PHARMACEUTICALS PLC | $75.2M | 2.17% | 3,100,902 | Common | SOLE |
| 83422E204 | SLDB | SOLID BIOSCIENCES INC | $73.0M | 2.11% | 11,833,539 | Common | SOLE |
| 74366E102 | PTGX | PROTAGONIST THERAPEUTICS INC | $68.4M | 1.98% | 1,030,134 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $63.2M | 1.82% | 450,050 | Common | SOLE |
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $61.6M | 1.78% | 3,795,894 | Common | SOLE |
| 925050106 | VRNA | VERONA PHARMA PLC | $55.9M | 1.61% | 524,088 | Common | SOLE |
| 70975L107 | PEN | PENUMBRA INC | $55.9M | 1.61% | 220,547 | Common | SOLE |
| 00973Y108 | AKRO | AKERO THERAPEUTICS INC | $53.9M | 1.56% | 1,135,766 | Common | SOLE |
| 03770N101 | APGE | APOGEE THERAPEUTICS INC | $53.7M | 1.55% | 1,351,989 | Common | SOLE |
| 68170A108 | OMDA | OMADA HEALTH INC | $53.0M | 1.53% | 2,396,330 | Common | SOLE |
| 03152W109 | AM6 | AMICUS THERAPEUTICS INC | $50.2M | 1.45% | 6,370,851 | Common | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $47.2M | 1.36% | 6,485,420 | Common | SOLE |
| 45720N103 | INBX | INHIBRX BIOSCIENCES INC | $44.7M | 1.29% | 1,327,707 | Common | SOLE |
| 759916109 | RGEN | REPLIGEN CORP | $36.1M | 1.04% | 270,428 | Common | SOLE |
| 98985Y108 | ZYME | ZYMEWORKS INC | $35.7M | 1.03% | 2,090,663 | Common | SOLE |
| 829401108 | SION | SIONNA THERAPEUTICS INC | $34.7M | 1.00% | 1,179,098 | Common | SOLE |
| 142152107 | CAI | CARIS LIFE SCIENCES INC | $33.2M | 0.96% | 1,098,163 | Common | SOLE |
| 00370M103 | ABVX | ABIVAX SA | $33.0M | 0.95% | 388,608 | Common | SOLE |
| 92790C104 | VRDN | VIRIDIAN THERAPEUTICS INC | $31.6M | 0.91% | 1,462,400 | Common | SOLE |
| 23284F105 | CTMX | CYTOMX THERAPEUTICS INC | $30.9M | 0.89% | 9,680,185 | Common | SOLE |
| 101137107 | BSX | BOSTON SCIENTIFIC CORP | $30.3M | 0.87% | 310,000 | Common | SOLE |
| 01438T106 | ALDX | ALDEYRA THERAPEUTICS INC | $27.3M | 0.79% | 5,222,311 | Common | SOLE |
| 10919W405 | DRUG | BRIGHT MINDS BIOSCIENCES INC | $27.3M | 0.79% | 449,290 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $25.6M | 0.74% | 1,587,890 | Common | SOLE |
| 30063P105 | EXK | EXACT SCIENCES CORP | $25.5M | 0.74% | 465,487 | Common | SOLE |
| 697947109 | PVLA | PALVELLA THERAPEUTICS INC NE | $24.8M | 0.72% | 395,093 | Common | SOLE |
| 687604108 | ORKA | ORUKA THERAPEUTICS INC | $24.4M | 0.70% | 1,268,021 | Common | SOLE |
| 46120E602 | ISRG | INTUITIVE SURGICAL INC | $23.3M | 0.67% | 52,119 | Common | SOLE |
| 450056106 | IRTC | IRHYTHM TECHNOLOGIES INC | $21.2M | 0.61% | 123,000 | Common | SOLE |
| 03843E104 | AQST | AQUESTIVE THERAPEUTICS INC | $21.0M | 0.61% | 3,760,099 | Common | SOLE |
| 00773J202 | SYRE | SPYRE THERAPEUTICS INC | $20.6M | 0.60% | 1,229,445 | Common | SOLE |
| 00534B100 | ADGM | ADAGIO MED HLDGS INC | $19.2M | 0.55% | 9,876,576 | Common | SOLE |
| 05464T104 | AXSM | AXSOME THERAPEUTICS INC | $18.1M | 0.52% | 148,900 | Common | SOLE |
| 000899104 | ADMA | ADMA BIOLOGICS INC | $16.9M | 0.49% | 1,153,468 | Common | SOLE |
| 29286M105 | — | ENGENE HOLDINGS INC | $14.3M | 0.41% | 2,097,236 | Common | SOLE |
| 68572M106 | OBIO | ORCHESTRA BIOMED HLDGS INC | $13.1M | 0.38% | 5,292,556 | Common | SOLE |
| 67080M103 | NRIX | NURIX THERAPEUTICS INC | $13.1M | 0.38% | 1,416,149 | Common | SOLE |
| 75383L102 | RAPP | RAPPORT THERAPEUTICS INC | $12.0M | 0.35% | 403,923 | Common | SOLE |
| 690145206 | OM | OUTSET MED INC | $11.8M | 0.34% | 833,333 | Common | SOLE |
| 63909J108 | NAUT | NAUTILUS BIOTECHNOLOGY INC | $10.6M | 0.31% | 12,594,211 | Common | SOLE |
| 221015100 | CRVS | CORVUS PHARMACEUTICALS INC | $10.6M | 0.31% | 1,438,595 | Common | SOLE |
| 50015M109 | KOD | KODIAK SCIENCES INC | $10.4M | 0.30% | 634,577 | Common | SOLE |
| 81734D104 | SEPN | SEPTERNA INC | $10.2M | 0.29% | 541,450 | Common | SOLE |
| 38341P102 | GOSS | GOSSAMER BIO INC | $10.0M | 0.29% | 3,812,797 | Common | SOLE |
| 501575104 | KYMR | KYMERA THERAPEUTICS INC | $9.6M | 0.28% | 169,796 | Common | SOLE |
| 45719W205 | IKT | INHIBIKASE THERAPEUTICS INC | $8.8M | 0.25% | 5,421,568 | Common | SOLE |
| 15102KAA8 | CELC 2.75 08/01/31 | CELCUITY INC | $8.7M | 0.25% | 6,500,000 | Common | SOLE |
| 21217B100 | CTNM | CONTINEUM THERAPEUTICS INC | $8.4M | 0.24% | 714,592 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $8.1M | 0.23% | 200,791 | Common | SOLE |
| 03675P102 | AVR | ANTERIS TECHNOLOGIES GLOBAL | $7.7M | 0.22% | 1,705,130 | Common | SOLE |
| 47103J105 | JANX | JANUX THERAPEUTICS INC | $7.2M | 0.21% | 292,686 | Common | SOLE |
| 67577R102 | IRD | OPUS GENETICS INC | $7.1M | 0.21% | 4,325,000 | Common | SOLE |
| 88023B103 | TEM | TEMPUS AI INC | $6.9M | 0.20% | 85,000 | Common | SOLE |
| 26818M108 | DYN | DYNE THERAPEUTICS INC | $6.8M | 0.20% | 540,444 | Common | SOLE |
| 501147102 | KRYS | KRYSTAL BIOTECH INC | $6.2M | 0.18% | 35,000 | Common | SOLE |
| 08659B102 | BBNX | BETA BIONICS INC | $5.5M | 0.16% | 277,944 | Common | SOLE |
| G2545C104 | CBIO | CRESCENT BIOPHARMA INC. | $5.4M | 0.16% | 453,686 | Common | SOLE |
| 42238D107 | HTFL | HEARTFLOW INC | $5.0M | 0.15% | 150,000 | Common | SOLE |
| 75382E208 | RAPT | RAPT THERAPEUTICS INC | $4.7M | 0.14% | 183,890 | Common | SOLE |
| 713317105 | PEPG | PEPGEN INC | $3.8M | 0.11% | 829,870 | Common | SOLE |
| 07782B104 | BLTE | BELITE BIO INC | $3.7M | 0.11% | 49,788 | Common | SOLE |
| 810648105 | SCPH | SCPHARMACEUTICALS INC | $3.3M | 0.10% | 583,142 | Common | SOLE |
| 92686J106 | VKTX | VIKING THERAPEUTICS INC | $2.8M | 0.08% | 105,597 | Common | SOLE |
| 747324101 | PYXS | PYXIS ONCOLOGY INC | $2.6M | 0.08% | 1,178,307 | Common | SOLE |
| 04746L203 | LONA | ATHIRA PHARMA INC | $2.2M | 0.06% | 540,296 | Common | SOLE |
| 82835W108 | SPRY | ARS PHARMACEUTICALS INC | $2.0M | 0.06% | 200,000 | PUT | SOLE |
| 896438504 | TRIB | TRINITY BIOTECH PLC | $1.9M | 0.05% | 1,790,000 | Common | SOLE |
| 05338F306 | AVTX | AVALO THERAPEUTICS INC | $1.8M | 0.05% | 139,667 | Common | SOLE |
| 29415J106 | NVNO | ENVVENO MEDICAL CORPORATION | $1.6M | 0.05% | 1,759,035 | Common | SOLE |
| 55234L204 | LYRA | LYRA THERAPEUTICS INC | $1.5M | 0.04% | 229,382 | Common | SOLE |
| N90064101 | QURE | UNIQURE NV | $1.2M | 0.03% | 20,000 | Common | SOLE |
| 52886X107 | LXEO | LEXEO THERAPEUTICS INC | $928,504 | 0.03% | 139,835 | Common | SOLE |
| 09075X207 | BDSX | BIODESIX | $820,639 | 0.02% | 108,694 | Common | SOLE |
| 02157Q109 | ANRO | ALTO NEUROSCIENCE INC | $624,571 | 0.02% | 155,366 | Common | SOLE |
| 03837C106 | APYX | APYX MEDICAL CORPORATION | $321,000 | 0.01% | 150,000 | Common | SOLE |
| 293602504 | ENSC | ENSYSCE BIOSCIENCES INC | $205,398 | 0.01% | 86,666 | Common | SOLE |
| 76155X118 | RVMDW | REVOLUTION MEDICINES INC | $74,975 | 0.00% | 250,000 | Common | SOLE |
| 86889P117 | SRZNW | SURROZEN INC | $2,967 | 0.00% | 166,666 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.