Q3 2025 · 13F-HR
DAFNA Capital Management LLCholdings as filed
Filed 2025-11-14 · accession 0001389933-25-000008
$404.8M
Reported value
75
Positions
2025-09-30
Period end
The Brief · DAFNA Capital Management LLC · Q3 2025
AI · grounded in 13F
DAFNA Capital Management LLC established a new position in Stereotaxis Inc STXS valued at $42.5M. The fund also initiated new stakes in SPDR S&P Biotech ETF XBI for $40.2M and Revolution Medicines Inc RVMD for $30.7M. Other new additions include Cytokinetics Inc CYTK and Atricure Inc ATRC.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 85916J409 | STXS | STEREOTAXIS INC | $42.5M | 10.5% | 13,680,554 | Common | SOLE |
| 78464A870 | XBI | SPDR S&P BIOTECH ETF | $40.2M | 9.94% | 401,505 | Common | SOLE |
| 76155X100 | RVMD | REVOLUTION MEDICINES INC | $30.7M | 7.58% | 657,176 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $21.7M | 5.36% | 394,940 | Common | SOLE |
| 04963C209 | ATRC | ATRICURE INC | $20.9M | 5.16% | 592,273 | Common | SOLE |
| N5749R100 | 2GH | MERUS BV | $20.8M | 5.13% | 220,451 | Common | SOLE |
| 464287556 | IBB | ISHARES NASDAQ BIOTECH INDX | $14.8M | 3.66% | 102,500 | Common | SOLE |
| 45166A102 | IDYA | IDEAYA BIOSCIENCES INC | $14.7M | 3.63% | 539,923 | Common | SOLE |
| 05463X106 | AXGN | AXOGEN INC | $13.2M | 3.27% | 742,282 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $11.6M | 2.86% | 287,939 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $9.9M | 2.45% | 70,615 | Common | SOLE |
| 03969F109 | RCUS | ARCUS BIOSCIENCES INC | $8.5M | 2.11% | 627,626 | Common | SOLE |
| 87164F105 | SNDX | SYNDAX PHARMACEUTICALS INC | $7.7M | 1.90% | 500,702 | Common | SOLE |
| 23954D109 | DAWNGBX | DAY ONE BIOPHARMACEUTICALS I | $7.0M | 1.74% | 999,163 | Common | SOLE |
| 04351P101 | ASNDUSD | ASCENDIS PHARMA A/S | $6.6M | 1.63% | 33,177 | Common | SOLE |
| 04351PAD3 | ASND 2.25 04/01/28 | ASCENDIS PHARMA A/S | $5.4M | 1.34% | 4,000,000 | Common | SOLE |
| 483497103 | KALV | KALVISTA PHARMACEUTICALS INC | $5.1M | 1.27% | 422,731 | Common | SOLE |
| 055477103 | BCAX | BICARA THERAPEUTICS INC | $5.0M | 1.24% | 317,001 | Common | SOLE |
| 45780L104 | INGN | INOGEN INC | $4.9M | 1.22% | 605,625 | Common | SOLE |
| 20451W101 | CMPS | COMPASS PATHWAYS PLC | $4.6M | 1.15% | 811,046 | Common | SOLE |
| 36315X101 | LKFT | GALAPAGOS NV | $4.5M | 1.11% | 130,175 | Common | SOLE |
| 252131107 | DXCM | DEXCOM INC | $4.4M | 1.09% | 65,552 | Common | SOLE |
| 875372203 | TNDM | TANDEM DIABETES CARE INC | $4.3M | 1.07% | 355,208 | Common | SOLE |
| 50127T109 | KURA | KURA ONCOLOGY INC | $4.1M | 1.01% | 463,368 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $4.0M | 1.00% | 134,748 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $4.0M | 0.99% | 169,791 | Common | SOLE |
| 834203309 | SLNO | SOLENO THERAPEUTICS INC | $3.6M | 0.89% | 53,000 | Common | SOLE |
| G1110E107 | BHVN | BIOHAVEN LTD | $3.5M | 0.87% | 235,235 | Common | SOLE |
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $3.5M | 0.86% | 213,736 | Common | SOLE |
| N71542109 | PRQR | PROQR THERAPEUTICS N V | $3.3M | 0.82% | 1,567,561 | Common | SOLE |
| 517125100 | LRMR | LARIMAR THERAPEUTICS INC | $3.3M | 0.82% | 1,027,764 | Common | SOLE |
| 20454B104 | CMPX | COMPASS THERAPEUTICS INC | $3.3M | 0.82% | 946,661 | Common | SOLE |
| 603170101 | MLYS | MINERALYS THERAPEUTICS INC | $3.2M | 0.78% | 83,490 | Common | SOLE |
| 640268306 | NKTR | NEKTAR THERAPEUTICS | $3.1M | 0.77% | 54,998 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $3.1M | 0.76% | 191,493 | Common | SOLE |
| 500946108 | KRRO | KORRO BIO INC | $2.9M | 0.72% | 60,804 | Common | SOLE |
| 03843E104 | AQST | AQUESTIVE THERAPEUTICS INC | $2.9M | 0.71% | 512,589 | Common | SOLE |
| 24823R105 | DNLI | DENALI THERAPEUTICS INC | $2.4M | 0.60% | 168,500 | Common | SOLE |
| 52886X107 | LXEO | LEXEO THERAPEUTICS INC | $2.4M | 0.59% | 358,083 | Common | SOLE |
| 014442107 | ALEC | ALECTOR INC | $2.4M | 0.58% | 798,351 | Common | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $2.3M | 0.58% | 319,775 | Common | SOLE |
| 75383L102 | RAPP | RAPPORT THERAPEUTICS INC | $2.2M | 0.55% | 75,000 | Common | SOLE |
| 872381108 | TELA | TELA BIO INC | $2.1M | 0.53% | 1,441,029 | Common | SOLE |
| 45784P101 | PODD | INSULET CORP | $2.1M | 0.52% | 6,870 | Common | SOLE |
| M68830112 | MDWD | MEDIWOUND LTD | $2.0M | 0.51% | 113,612 | Common | SOLE |
| 004397105 | ARAY | ACCURAY INC | $2.0M | 0.50% | 1,222,358 | Common | SOLE |
| N44445109 | IMTX | IMMATICS NV | $2.0M | 0.49% | 235,000 | Common | SOLE |
| 019770106 | ALLO | ALLOGENE THERAPEUTICS INC | $1.7M | 0.42% | 1,380,118 | Common | SOLE |
| 92686J106 | VKTX | VIKING THERAPEUTICS INC | $1.7M | 0.42% | 64,516 | Common | SOLE |
| 09058V103 | BCRX | BIOCRYST PHARMACEUTICALS INC | $1.7M | 0.41% | 218,255 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $1.7M | 0.41% | 59,000 | Common | SOLE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $1.5M | 0.37% | 85,000 | Common | SOLE |
| 82835W108 | SPRY | ARS PHARMACEUTICALS INC | $1.4M | 0.35% | 140,500 | Common | SOLE |
| 016255101 | ALGN | ALIGN TECHNOLOGY INC | $1.4M | 0.34% | 11,000 | Common | SOLE |
| 492327101 | KROS | KEROS THERAPEUTICS INC | $1.3M | 0.32% | 80,716 | Common | SOLE |
| 457730109 | INSP | INSPIRE MEDICAL SYSTEMS INC | $1.3M | 0.32% | 17,200 | Common | SOLE |
| 68622P109 | ORIC | ORIC PHARMACEUTICALS INC | $1.3M | 0.31% | 104,671 | Common | SOLE |
| 09203E105 | BDTX | BLACK DIAMOND THERAPEUTICS I | $1.2M | 0.29% | 307,070 | Common | SOLE |
| 68572M106 | OBIO | ORCHESTRA BIOMED HOLDINGS INC | $901,817 | 0.22% | 363,636 | Common | SOLE |
| 10501L106 | BWAY | BRAINSWAY LTD | $858,478 | 0.21% | 56,966 | Common | SOLE |
| 15673T100 | IPSC | CENTURY THERAPEUTICS INC | $848,708 | 0.21% | 1,704,232 | Common | SOLE |
| 29479A108 | ERAS | ERASCA INC | $763,000 | 0.19% | 350,000 | Common | SOLE |
| M8001Q126 | PYPD | POLYPID LTD | $693,347 | 0.17% | 207,900 | Common | SOLE |
| 09075V102 | BNTX | BIONTECH SE | $690,340 | 0.17% | 7,000 | Common | SOLE |
| 15117B202 | CLDX | CELLDEX THERAPEUTICS INC NEW | $634,281 | 0.16% | 24,518 | Common | SOLE |
| 344174107 | FHTX | FOGHORN THERAPEUTICS INC | $620,341 | 0.15% | 126,859 | Common | SOLE |
| M96088105 | URGN | UROGEN PHARMA LTD | $548,924 | 0.14% | 27,515 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $526,399 | 0.13% | 30,375 | Common | SOLE |
| 088786108 | BCYC | BICYCLE THERAPEUTICS PLC | $499,168 | 0.12% | 64,492 | Common | SOLE |
| H0036K147 | ADCT | ADC THERAPEUTICS SA | $488,324 | 0.12% | 122,081 | Common | SOLE |
| M25722105 | CGEN | COMPUGEN LTD | $400,431 | 0.10% | 272,402 | Common | SOLE |
| 869367102 | STRO | SUTRO BIOPHARMA INC | $379,559 | 0.09% | 437,079 | Common | SOLE |
| 05280R100 | AUTL | AUTOLUS THERAPEUTICS PLC | $292,285 | 0.07% | 179,316 | Common | SOLE |
| 09090D301 | PHGE | BIOMX INC | $210,596 | 0.05% | 401,136 | Common | SOLE |
| 03836J201 | APRE | APREA THERAPEUTICS INC | $202,332 | 0.05% | 137,174 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.