Q4 2025 · 13F-HR
DAFNA Capital Management LLCholdings as filed
Filed 2026-02-17 · accession 0001389933-26-000002
$430.5M
Reported value
77
Positions
2025-12-31
Period end
The Brief · DAFNA Capital Management LLC · Q4 2025
AI · grounded in 13F
DAFNA Capital Management LLC closed its position in Merus BV 2GH, reducing exposure by $20.76M. The fund established new positions in Procept BioRobotics Corp PRCT for $3.78M and Cybin Inc HELP for $3.72M. Additionally, the manager increased its stake in Biohaven Ltd BHVN by 306.08% and MBX Biosciences Inc MBX by 94.43%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 76155X100 | RVMD | REVOLUTION MEDICINES INC | $48.1M | 11.2% | 604,514 | Common | SOLE |
| 78464A870 | XBI | SPDR S&P BIOTECH ETF | $41.0M | 9.53% | 336,505 | Common | SOLE |
| 85916J409 | STXS | STEREOTAXIS INC | $31.5M | 7.31% | 13,680,554 | Common | SOLE |
| 04963C209 | ATRC | ATRICURE INC | $23.6M | 5.49% | 597,431 | Common | SOLE |
| 23282W605 | CYTK | CYTOKINETICS INC | $23.6M | 5.48% | 370,997 | Common | SOLE |
| 45166A102 | IDYA | IDEAYA BIOSCIENCES INC | $17.5M | 4.07% | 506,740 | Common | SOLE |
| 05463X106 | AXGN | AXOGEN INC | $15.6M | 3.63% | 476,826 | Common | SOLE |
| 98420N105 | XENE | XENON PHARMACEUTICALS INC | $12.9M | 3.00% | 287,939 | Common | SOLE |
| 464287556 | IBB | ISHARES NASDAQ BIOTECH INDX | $11.5M | 2.67% | 68,095 | Common | SOLE |
| G1110E107 | BHVN | BIOHAVEN LTD | $10.8M | 2.51% | 955,235 | Common | SOLE |
| 03969F109 | RCUS | ARCUS BIOSCIENCES INC | $10.3M | 2.39% | 431,329 | Common | SOLE |
| 64125C109 | NBIX | NEUROCRINE BIOSCIENCES INC | $10.0M | 2.33% | 70,615 | Common | SOLE |
| 23954D109 | DAWNGBX | DAY ONE BIOPHARMACEUTICALS I | $9.3M | 2.16% | 999,163 | Common | SOLE |
| 875372203 | TNDM | TANDEM DIABETES CARE INC | $7.8M | 1.81% | 355,208 | Common | SOLE |
| 04351P101 | ASNDUSD | ASCENDIS PHARMA A/S | $6.0M | 1.40% | 28,177 | Common | SOLE |
| 252131107 | DXCM | DEXCOM INC | $5.9M | 1.36% | 88,279 | Common | SOLE |
| 87164F105 | SNDX | SYNDAX PHARMACEUTICALS INC | $5.8M | 1.36% | 277,855 | Common | SOLE |
| 483497103 | KALV | KALVISTA PHARMACEUTICALS INC | $5.8M | 1.34% | 356,802 | Common | SOLE |
| 20451W101 | CMPS | COMPASS PATHWAYS PLC | $5.6M | 1.30% | 811,046 | Common | SOLE |
| 45780L104 | INGN | INOGEN INC | $5.6M | 1.29% | 827,071 | Common | SOLE |
| 04351PAD3 | ASND 2.25 04/01/28 | ASCENDIS PHARMA A/S | $5.5M | 1.27% | 4,000,000 | Common | SOLE |
| 24823R105 | DNLI | DENALI THERAPEUTICS INC | $5.3M | 1.22% | 318,500 | Common | SOLE |
| 55287L101 | MBX | MBX BIOSCIENCES INC | $5.2M | 1.21% | 165,265 | Common | SOLE |
| 055477103 | BCAX | BICARA THERAPEUTICS INC | $4.4M | 1.02% | 261,583 | Common | SOLE |
| 36315X101 | LKFT | GALAPAGOS NV | $4.3M | 0.99% | 130,175 | Common | SOLE |
| 04635X102 | CATBUSD | ASTRIA THERAPEUTICS INC | $4.0M | 0.93% | 304,775 | Common | SOLE |
| 28036F105 | EWTX | EDGEWISE THERAPEUTICS INC | $4.0M | 0.92% | 159,736 | Common | SOLE |
| 45258J102 | IMVT | IMMUNOVANT INC | $3.8M | 0.89% | 150,524 | Common | SOLE |
| 74276L105 | PRCT | PROCEPT BIOROBOTICS CORP | $3.8M | 0.88% | 120,000 | Common | SOLE |
| 23256X407 | HELP | CYBIN INC | $3.7M | 0.86% | 455,018 | Common | SOLE |
| G01767105 | ALKS | ALKERMES PLC | $3.6M | 0.85% | 130,248 | Common | SOLE |
| 517125100 | LRMR | LARIMAR THERAPEUTICS INC | $3.6M | 0.83% | 939,164 | Common | SOLE |
| 86150R107 | STOK | STOKE THERAPEUTICS INC | $3.5M | 0.80% | 108,875 | Common | SOLE |
| 52886X107 | LXEO | LEXEO THERAPEUTICS INC | $3.4M | 0.79% | 340,859 | Common | SOLE |
| 09058V103 | BCRX | BIOCRYST PHARMACEUTICALS INC | $3.3M | 0.76% | 418,255 | Common | SOLE |
| 640268306 | NKTR | NEKTAR THERAPEUTICS | $3.2M | 0.74% | 74,998 | Common | SOLE |
| N71542109 | PRQR | PROQR THERAPEUTICS N V | $3.2M | 0.74% | 1,567,561 | Common | SOLE |
| 15673T100 | IPSC | CENTURY THERAPEUTICS INC | $2.8M | 0.65% | 2,793,586 | Common | SOLE |
| N44445109 | IMTX | IMMATICS NV | $2.7M | 0.64% | 261,138 | Common | SOLE |
| 86366E106 | GPCR | STRUCTURE THERAPEUTICS INC | $2.6M | 0.60% | 37,000 | Common | SOLE |
| 56565P103 | MPLT | MAPLIGHT THERAPEUTICS INC | $2.5M | 0.59% | 143,764 | Common | SOLE |
| 016255101 | ALGN | ALIGN TECHNOLOGY INC | $2.5M | 0.58% | 16,000 | Common | SOLE |
| 50127T109 | KURA | KURA ONCOLOGY INC | $2.5M | 0.57% | 235,868 | Common | SOLE |
| 03843E104 | AQST | AQUESTIVE THERAPEUTICS INC | $2.4M | 0.56% | 375,915 | Common | SOLE |
| 75383L102 | RAPP | RAPPORT THERAPEUTICS INC | $2.3M | 0.53% | 75,000 | Common | SOLE |
| 74319B502 | PROF | PROFOUND MEDICAL CORP | $2.2M | 0.52% | 285,710 | Common | SOLE |
| 82835W108 | SPRY | ARS PHARMACEUTICALS INC | $2.2M | 0.51% | 190,065 | Common | SOLE |
| M68830112 | MDWD | MEDIWOUND LTD | $2.1M | 0.49% | 113,612 | Common | SOLE |
| 92686J106 | VKTX | VIKING THERAPEUTICS INC | $2.1M | 0.49% | 59,516 | Common | SOLE |
| 45784P101 | PODD | INSULET CORP | $2.0M | 0.45% | 6,870 | Common | SOLE |
| 019770106 | ALLO | ALLOGENE THERAPEUTICS INC | $1.9M | 0.44% | 1,380,118 | Common | SOLE |
| 15117B202 | CLDX | CELLDEX THERAPEUTICS INC NEW | $1.9M | 0.43% | 68,518 | Common | SOLE |
| 872381108 | TELA | TELA BIO INC | $1.7M | 0.39% | 1,441,029 | Common | SOLE |
| 29286M105 | — | ENGENE HOLDINGS INC | $1.5M | 0.34% | 163,645 | Common | SOLE |
| 92511W207 | VRCA | VERRICA PHARMACEUTICALS INC | $1.4M | 0.33% | 173,451 | Common | SOLE |
| 014442107 | ALEC | ALECTOR INC | $1.4M | 0.33% | 908,351 | Common | SOLE |
| 603170101 | MLYS | MINERALYS THERAPEUTICS INC | $1.4M | 0.32% | 38,490 | Common | SOLE |
| 03589W102 | ANNX | ANNEXON INC | $1.4M | 0.32% | 272,812 | Common | SOLE |
| 68622P109 | ORIC | ORIC PHARMACEUTICALS INC | $1.2M | 0.27% | 141,045 | Common | SOLE |
| 004397105 | ARAY | ACCURAY INC | $1.2M | 0.27% | 1,395,508 | Common | SOLE |
| 29479A108 | ERAS | ERASCA INC | $946,502 | 0.22% | 254,436 | Common | SOLE |
| M8001Q126 | PYPD | POLYPID LTD | $902,286 | 0.21% | 207,900 | Common | SOLE |
| 457730109 | INSP | INSPIRE MEDICAL SYSTEMS INC | $793,178 | 0.18% | 8,600 | Common | SOLE |
| 007002207 | ACET | ADICET BIO INC | $789,897 | 0.18% | 93,812 | Common | SOLE |
| 344174107 | FHTX | FOGHORN THERAPEUTICS INC | $685,039 | 0.16% | 126,859 | Common | SOLE |
| 09075V102 | BNTX | BIONTECH SE | $666,400 | 0.15% | 7,000 | Common | SOLE |
| 64135M105 | NGNE | NEUROGENE INC | $576,264 | 0.13% | 27,974 | Common | SOLE |
| 31189P102 | FATE | FATE THERAPEUTICS INC | $540,430 | 0.13% | 550,000 | Common | SOLE |
| 68572M106 | OBIO | ORCHESTRA BIOMED HOLDINGS INC | $526,390 | 0.12% | 126,841 | Common | SOLE |
| 088786108 | BCYC | BICYCLE THERAPEUTICS PLC | $456,603 | 0.11% | 64,492 | Common | SOLE |
| M25722105 | CGEN | COMPUGEN LTD | $416,775 | 0.10% | 272,402 | Common | SOLE |
| 48576U205 | KPTI | KARYOPHARM THERAPEUTICS | $375,360 | 0.09% | 51,000 | Common | SOLE |
| 90400D108 | RARE | ULTRAGENYX PHARMACEUTICAL INC | $368,000 | 0.09% | 16,000 | Common | SOLE |
| 05280R100 | AUTL | AUTOLUS THERAPEUTICS PLC | $356,839 | 0.08% | 179,316 | Common | SOLE |
| H0036K147 | ADCT | ADC THERAPEUTICS SA | $272,096 | 0.06% | 77,081 | Common | SOLE |
| 10501L106 | BWAY | BRAINSWAY LTD | $246,594 | 0.06% | 12,965 | Common | SOLE |
| 46489V302 | CATX | PERSPECTIVE THERAPEUTICS INC | $137,500 | 0.03% | 50,000 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.