Q3 2024 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2024-11-13 · accession 0002005245-24-000005
$2.00B
Reported value
112
Positions
2024-09-30
Period end
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 501575104 | KYMR | Kymera Therapeutics Inc | $140.6M | 7.03% | 2,969,733 | Common | SOLE |
| 07725L102 | ONC | Beigene Ltd | $126.5M | 6.32% | 563,314 | Common | SOLE |
| 80706P103 | SRRK | Scholar Rock Holding Corp | $90.2M | 4.51% | 11,259,438 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $78.3M | 3.91% | 3,072,827 | Common | SOLE |
| 04016X101 | ARGX | Argenx SE | $77.9M | 3.89% | 143,647 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $66.9M | 3.35% | 1,309,652 | Common | SOLE |
| 05370A108 | RNAGBP | Avidity Biosciences Inc | $66.2M | 3.31% | 1,440,736 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $62.5M | 3.12% | 2,167,224 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $61.1M | 3.05% | 38,918,903 | Common | SOLE |
| 449585108 | 1K0 | IGM Biosciences Inc | $55.1M | 2.75% | 3,330,422 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $52.1M | 2.60% | 3,258,677 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $51.9M | 2.60% | 347,921 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $51.5M | 2.57% | 2,831,770 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $47.6M | 2.38% | 2,458,778 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $46.9M | 2.35% | 5,721,172 | Common | SOLE |
| 85205L107 | SWTXUSD | SpringWorks Therapeutics Inc | $44.1M | 2.21% | 1,377,701 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $40.8M | 2.04% | 1,134,664 | Common | SOLE |
| 92337R101 | VERA | Vera Therapeutics Inc | $37.0M | 1.85% | 837,928 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $34.4M | 1.72% | 2,606,571 | Common | SOLE |
| 92243G108 | PCVX | Vaxcyte Inc | $34.3M | 1.71% | 299,991 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $34.2M | 1.71% | 753,601 | Common | SOLE |
| N5749R100 | 2GH | Merus NV | $34.1M | 1.70% | 682,201 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $33.5M | 1.67% | 9,969,495 | Common | SOLE |
| 54300N103 | — | Longboard Pharmaceuticals Inc | $30.1M | 1.50% | 903,227 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $29.3M | 1.46% | 743,769 | Common | SOLE |
| 23282W605 | CYTK | Cytokinetics Inc | $27.8M | 1.39% | 525,971 | Common | SOLE |
| 50127T109 | KURA | Kura Oncology Inc | $26.2M | 1.31% | 1,339,942 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $24.6M | 1.23% | 1,612,077 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $24.3M | 1.21% | 834,028 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $24.2M | 1.21% | 8,857,179 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $20.3M | 1.01% | 1,211,357 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $20.1M | 1.00% | 2,603,897 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $19.2M | 0.96% | 2,749,041 | Common | SOLE |
| G72800108 | PRTA | Prothena Corporation PLC | $18.4M | 0.92% | 1,099,840 | Common | SOLE |
| N62509109 | NAMS | NewAmsterdam Pharma Company NV | $15.3M | 0.76% | 920,564 | Common | SOLE |
| G1110E107 | BHVN | Biohaven Ltd | $14.2M | 0.71% | 283,540 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $14.0M | 0.70% | 418,833 | Common | SOLE |
| 03828A101 | APLT | Applied Therapeutics Inc | $13.9M | 0.69% | 1,633,768 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $13.1M | 0.65% | 13,281,610 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $13.0M | 0.65% | 192,433 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $10.8M | 0.54% | 404,113 | Common | SOLE |
| 462260100 | IOVA | Iovance Biotherapeutics Inc | $10.4M | 0.52% | 1,106,040 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $10.3M | 0.52% | 1,007,575 | Common | SOLE |
| 462222100 | IONS | Ionis Pharmaceuticals Inc | $10.0M | 0.50% | 250,000 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $9.8M | 0.49% | 4,879,875 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $9.5M | 0.47% | 22,000 | Common | SOLE |
| 816212302 | RNAC | Cartesian Therapeutics Inc | $9.2M | 0.46% | 572,236 | Common | SOLE |
| 00445A100 | — | ACELYRIN Inc | $8.5M | 0.43% | 1,729,665 | Common | SOLE |
| 71722W107 | PHAT | Phathom Pharmaceuticals Inc | $8.3M | 0.42% | 460,753 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $7.9M | 0.39% | 4,000,000 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $7.9M | 0.39% | 384,197 | Common | SOLE |
| 64135M105 | NGNE | Neurogene Inc | $7.4M | 0.37% | 175,898 | Common | SOLE |
| 37148K100 | GBIOGBX | Generation Bio Co | $7.4M | 0.37% | 2,982,733 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $7.0M | 0.35% | 2,357,520 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $7.0M | 0.35% | 25,000 | Common | SOLE |
| 92673K108 | VIGL | Vigil Neuroscience Inc | $6.8M | 0.34% | 1,991,038 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc. | $6.7M | 0.34% | 720,720 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $6.7M | 0.34% | 7,500 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $6.5M | 0.32% | 34,750 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE Labs Inc | $6.2M | 0.31% | 300,000 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $5.9M | 0.30% | 48,932 | Common | SOLE |
| 87184Q206 | SYRS | Syros Pharmaceuticals Inc | $5.6M | 0.28% | 2,587,372 | Common | SOLE |
| G6674U108 | NVCR | Novocure Ltd | $5.5M | 0.27% | 350,884 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $5.5M | 0.27% | 603,435 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $5.4M | 0.27% | 40,401 | Common | SOLE |
| 019818103 | — | Allovir Inc | $5.3M | 0.27% | 6,597,167 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $4.6M | 0.23% | 1,046,517 | Common | SOLE |
| 02157Q109 | ANRO | Alto Neuroscience Inc | $4.5M | 0.22% | 391,406 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $4.4M | 0.22% | 82,729 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $4.4M | 0.22% | 500,000 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $4.3M | 0.22% | 25,000 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $4.2M | 0.21% | 775,000 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $3.8M | 0.19% | 32,925 | Common | SOLE |
| H0036K147 | ADCT | ADC Therapeutics SA | $3.7M | 0.18% | 1,163,461 | Common | SOLE |
| 81141R100 | SE | Sea Ltd | $3.5M | 0.18% | 37,500 | Common | SOLE |
| 690469101 | OVID | Ovid Therapeutics Inc | $3.4M | 0.17% | 2,850,000 | Common | SOLE |
| 75901B107 | RGNX | Regenxbio Inc | $3.0M | 0.15% | 284,000 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $2.9M | 0.15% | 38,500 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.6M | 0.13% | 15,000 | Common | SOLE |
| 43906K209 | HOOK | HOOKIPA Pharma Inc | $2.4M | 0.12% | 566,640 | Common | SOLE |
| 89157D105 | TRML | Tourmaline Bio Inc | $2.4M | 0.12% | 91,426 | Common | SOLE |
| 70450Y103 | PYPL | PayPal Holdings Inc | $2.0M | 0.10% | 26,000 | CALL | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $2.0M | 0.10% | 724,771 | Common | SOLE |
| 74275K108 | PCOR | Procore Technologies Inc | $2.0M | 0.10% | 32,300 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $2.0M | 0.10% | 100,000 | Common | SOLE |
| 92826C839 | V | Visa Inc | $1.9M | 0.10% | 7,000 | Common | SOLE |
| 39868T105 | 2JQ | Gritstone bio Inc | $1.9M | 0.10% | 3,318,093 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $1.8M | 0.09% | 11,000 | Common | SOLE |
| 674599105 | OXY | Occidental Petroleum Corp | $1.8M | 0.09% | 35,000 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $1.8M | 0.09% | 61,000 | Common | SOLE |
| 68217N105 | — | Omega Therapeutics Inc | $1.6M | 0.08% | 1,323,530 | Common | SOLE |
| 632307104 | NTRA | Natera Inc | $1.6M | 0.08% | 12,594 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $1.5M | 0.08% | 4,500 | Common | SOLE |
| 70450Y103 | PYPL | PayPal Holdings Inc | $1.2M | 0.06% | 15,000 | Common | SOLE |
| N14506104 | ESTC | Elastic NV | $997,880 | 0.05% | 13,000 | Common | SOLE |
| 458140100 | INTC | Intel Corp | $938,400 | 0.05% | 40,000 | Common | SOLE |
| 30303M102 | META | Meta Platforms Inc | $858,660 | 0.04% | 1,500 | Common | SOLE |
| 50107A104 | KRON1USD | Kronos Bio Inc | $842,870 | 0.04% | 842,954 | Common | SOLE |
| 880881107 | 430 | Terns Pharmaceuticals Inc | $834,000 | 0.04% | 100,000 | Common | SOLE |
| 781154109 | RBRK | Rubrik Inc | $803,750 | 0.04% | 25,000 | Common | SOLE |
| 00449L102 | 698 | Achilles Therapeutics PLC | $770,483 | 0.04% | 755,375 | Common | SOLE |
| 256746108 | DLTR | Dollar Tree Inc | $703,200 | 0.04% | 10,000 | Common | SOLE |
| G6683N103 | NU | Nu Holdings Ltd | $682,500 | 0.03% | 50,000 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $517,780 | 0.03% | 1,000 | Common | SOLE |
| 46333X108 | IRWD | Ironwood Pharmaceuticals Inc | $455,392 | 0.02% | 110,532 | Common | SOLE |
| 48553T106 | BZ | Kanzhun Ltd | $434,000 | 0.02% | 25,000 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $334,750 | 0.02% | 25,000 | Common | SOLE |
| 38000Q102 | GLYCEUR | GlycoMimetics Inc | $332,104 | 0.02% | 1,965,114 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $300,841 | 0.02% | 116,155 | Common | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $206,480 | 0.01% | 105,347 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $204,185 | 0.01% | 207,000 | CALL | SOLE |
| G7185D114 | — | Perception Capital Corp III | $3,800 | 0.00% | 126,666 | CALL | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.