Q4 2024 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2025-02-14 · accession 0002005245-25-000002
$2.26B
Reported value
118
Positions
2024-12-31
Period end
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $399.8M | 17.7% | 9,250,005 | Common | SOLE |
| 07725L102 | ONC | Beigene Ltd | $120.7M | 5.33% | 653,721 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $119.5M | 5.28% | 2,969,733 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $89.9M | 3.97% | 2,816,258 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $82.3M | 3.64% | 1,609,652 | Common | SOLE |
| 04016X101 | ARGX | argenx SE | $70.8M | 3.13% | 115,045 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $57.0M | 2.52% | 3,272,827 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $54.6M | 2.41% | 2,901,681 | Common | SOLE |
| N62509109 | NAMS | NewAmsterdam Pharma Company NV | $53.9M | 2.38% | 2,095,638 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $50.4M | 2.23% | 2,202,514 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $50.3M | 2.22% | 3,004,677 | Common | SOLE |
| 85205L107 | SWTXUSD | SpringWorks Therapeutics Inc | $49.8M | 2.20% | 1,377,701 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $46.6M | 2.06% | 4,396,100 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $46.4M | 2.05% | 3,750,491 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $40.9M | 1.81% | 297,321 | Common | SOLE |
| 558868105 | MDGL | Madrigal Pharmaceuticals Inc | $38.9M | 1.72% | 125,942 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $36.4M | 1.61% | 9,969,495 | Common | SOLE |
| 03770N101 | APGE | Apogee Therapeutics Inc | $33.9M | 1.50% | 747,325 | Common | SOLE |
| N5749R100 | 2GH | Merus NV | $33.0M | 1.46% | 784,412 | Common | SOLE |
| 05370A108 | RNAGBP | Avidity Biosciences Inc | $32.8M | 1.45% | 1,127,295 | Common | SOLE |
| 92337R101 | VERA | Vera Therapeutics Inc | $32.1M | 1.42% | 758,465 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $31.7M | 1.40% | 1,347,456 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $29.2M | 1.29% | 743,769 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $28.8M | 1.27% | 38,918,903 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $25.8M | 1.14% | 1,839,398 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $25.0M | 1.10% | 571,548 | Common | SOLE |
| 92243G108 | PCVX | Vaxcyte Inc | $24.6M | 1.08% | 299,991 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $24.0M | 1.06% | 1,612,077 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $22.2M | 0.98% | 8,857,179 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $22.1M | 0.97% | 2,000,000 | Common | SOLE |
| 449585108 | 1K0 | IGM Biosciences Inc | $20.3M | 0.90% | 3,330,422 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $19.6M | 0.87% | 734,343 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $19.5M | 0.86% | 2,831,770 | Common | SOLE |
| 23282W605 | CYTK | Cytokinetics Inc | $18.9M | 0.84% | 402,323 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $17.0M | 0.75% | 834,028 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $15.9M | 0.70% | 418,833 | Common | SOLE |
| 834203309 | SLNO | Soleno Therapeutics Inc | $15.8M | 0.70% | 351,818 | Common | SOLE |
| G72800108 | PRTA | Prothena Corporation PLC | $15.2M | 0.67% | 1,099,840 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $15.0M | 0.66% | 3,749,041 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $14.8M | 0.65% | 1,211,357 | Common | SOLE |
| 91678A107 | UPB | Upstream Bio Inc | $13.2M | 0.58% | 800,000 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $12.0M | 0.53% | 2,906,060 | Common | SOLE |
| 50127T109 | KURA | Kura Oncology Inc | $11.7M | 0.52% | 1,339,942 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $11.4M | 0.50% | 6,602,475 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $11.1M | 0.49% | 490,449 | Common | SOLE |
| 816212302 | RNAC | Cartesian Therapeutics Inc | $10.2M | 0.45% | 572,236 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $9.7M | 0.43% | 23,000 | Common | SOLE |
| 47103J105 | JANX | Janux Therapeutics Inc | $9.4M | 0.41% | 175,000 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $9.2M | 0.41% | 4,000,000 | Common | SOLE |
| 462222100 | IONS | Ionis Pharmaceuticals Inc | $8.7M | 0.39% | 250,000 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $8.7M | 0.38% | 374,000 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $8.2M | 0.36% | 24,000 | Common | SOLE |
| 462260100 | IOVA | Iovance Biotherapeutics Inc | $8.2M | 0.36% | 1,106,040 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $8.1M | 0.36% | 1,007,575 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $8.0M | 0.36% | 2,603,897 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $8.0M | 0.35% | 36,500 | Common | SOLE |
| 77313F106 | RCKT | Rocket Pharmaceuticals Inc | $7.5M | 0.33% | 600,000 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $7.1M | 0.31% | 170,000 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $6.9M | 0.30% | 2,357,520 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $6.8M | 0.30% | 384,197 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $6.6M | 0.29% | 48,932 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $5.9M | 0.26% | 5,605 | Common | SOLE |
| 00445A100 | — | ACELYRIN Inc | $5.4M | 0.24% | 1,729,665 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $5.1M | 0.23% | 52,901 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $4.7M | 0.21% | 5,208,968 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $4.5M | 0.20% | 82,729 | Common | SOLE |
| 097023105 | BA | Boeing Co | $4.4M | 0.20% | 25,000 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $4.4M | 0.19% | 68,500 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $4.3M | 0.19% | 30,425 | Common | SOLE |
| N71542109 | PRQR | ProQR Therapeutics NV | $4.2M | 0.18% | 1,575,000 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $4.0M | 0.18% | 603,435 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $3.9M | 0.17% | 8,798 | Common | SOLE |
| 71722W107 | PHAT | Phathom Pharmaceuticals Inc | $3.7M | 0.17% | 460,753 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $3.7M | 0.16% | 192,433 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $3.5M | 0.16% | 120,116 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc. | $3.4M | 0.15% | 720,720 | Common | SOLE |
| 92673K108 | VIGL | Vigil Neuroscience Inc | $3.4M | 0.15% | 1,991,038 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $3.3M | 0.15% | 120,000 | Common | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $3.3M | 0.14% | 724,771 | Common | SOLE |
| 37148K100 | GBIOGBX | Generation Bio Co | $3.2M | 0.14% | 2,982,733 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $3.0M | 0.13% | 15,000 | Common | SOLE |
| 35671D857 | FCX | Freeport-McMoRan Inc | $2.9M | 0.13% | 75,000 | Common | SOLE |
| 019818103 | — | Allovir Inc | $2.8M | 0.12% | 6,597,167 | Common | SOLE |
| 690469101 | OVID | Ovid Therapeutics Inc | $2.7M | 0.12% | 2,850,000 | Common | SOLE |
| 81141R100 | SE | Sea Ltd | $2.7M | 0.12% | 25,000 | Common | SOLE |
| N14506104 | ESTC | Elastic NV | $2.5M | 0.11% | 25,000 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.3M | 0.10% | 15,000 | Common | SOLE |
| 09077V100 | BIOA | BIOAGE Labs Inc | $2.2M | 0.10% | 388,000 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $2.2M | 0.10% | 1,046,517 | Common | SOLE |
| 75901B107 | RGNX | Regenxbio Inc | $2.2M | 0.10% | 284,000 | Common | SOLE |
| 89157D105 | TRML | Tourmaline Bio Inc | $1.9M | 0.08% | 91,426 | Common | SOLE |
| 74275K108 | PCOR | Procore Technologies Inc | $1.5M | 0.07% | 20,000 | Common | SOLE |
| 03828A101 | APLT | Applied Therapeutics Inc | $1.4M | 0.06% | 1,633,768 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $1.3M | 0.06% | 7,000 | Common | SOLE |
| 70450Y103 | PYPL | PayPal Holdings Inc | $1.3M | 0.06% | 15,000 | Common | SOLE |
| 43906K209 | HOOK | HOOKIPA Pharma Inc | $1.1M | 0.05% | 566,640 | Common | SOLE |
| 40412C101 | HCA | HCA Healthcare Inc | $1.1M | 0.05% | 3,750 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $1.1M | 0.05% | 60,000 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $1.1M | 0.05% | 10,000 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $1.1M | 0.05% | 6,000 | Common | SOLE |
| 68217N105 | — | Omega Therapeutics Inc | $986,824 | 0.04% | 1,323,530 | Common | SOLE |
| 22207T101 | BASE | Couchbase Inc | $935,400 | 0.04% | 60,000 | Common | SOLE |
| 00449L102 | 698 | Achilles Therapeutics PLC | $861,128 | 0.04% | 755,375 | Common | SOLE |
| N3167Y103 | RACE | Ferrari NV | $854,493 | 0.04% | 2,000 | Common | SOLE |
| 458140100 | INTC | Intel Corp | $802,000 | 0.04% | 40,000 | Common | SOLE |
| 50107A104 | KRON1USD | Kronos Bio Inc | $800,806 | 0.04% | 842,954 | Common | SOLE |
| 256746108 | DLTR | Dollar Tree Inc | $749,400 | 0.03% | 10,000 | Common | SOLE |
| 674599105 | OXY | Occidental Petroleum Corp | $741,150 | 0.03% | 15,000 | Common | SOLE |
| 30303M102 | META | Meta Platforms Inc | $585,510 | 0.03% | 1,000 | Common | SOLE |
| 573874104 | MRVL | Marvell Technology Inc | $552,250 | 0.02% | 5,000 | Common | SOLE |
| G6683N103 | NU | Nu Holdings Ltd | $518,000 | 0.02% | 50,000 | Common | SOLE |
| 46333X108 | IRWD | Ironwood Pharmaceuticals Inc | $489,657 | 0.02% | 110,532 | Common | SOLE |
| M7S64H106 | MNDY | Monday.Com Ltd | $470,880 | 0.02% | 2,000 | Common | SOLE |
| 81686C104 | 628 | SEMrush Holdings Inc | $415,800 | 0.02% | 35,000 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $374,019 | 0.02% | 116,155 | Common | SOLE |
| 48553T106 | BZ | Kanzhun Ltd | $345,000 | 0.02% | 25,000 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $187,252 | 0.01% | 207,000 | CALL | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $167,502 | 0.01% | 105,347 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.