Q4 2025 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2026-02-13 · accession 0002005245-26-000003
$3.35B
Reported value
113
Positions
2025-12-31
Period end
The Brief · Siren, L.L.C. · Q4 2025
AI · grounded in 13F
Siren, L.L.C. established a new position in Olema Pharmaceuticals Inc OLMA valued at $82.5M. The fund closed its position in Avidity Biosciences Inc RNAGBP, reducing exposure by $56M, and exited Rezolute Inc RZLT for $45.8M. Additionally, the fund increased its holdings in Revolution Medicines Inc RVMD by 27.9% and Scholar Rock Holding Corp SRRK by 17%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $476.8M | 14.2% | 10,825,013 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $255.7M | 7.63% | 3,286,830 | Common | SOLE |
| 07725L102 | ONC | BeOne Medicines AG | $151.9M | 4.53% | 500,000 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $112.4M | 3.35% | 4,529,990 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $106.3M | 3.17% | 1,335,075 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $100.7M | 3.00% | 4,027,517 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $99.6M | 2.97% | 1,500,476 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $87.8M | 2.62% | 5,216,969 | Common | SOLE |
| 68062P106 | OLMA | Olema Pharmaceuticals Inc | $82.5M | 2.46% | 3,300,700 | Common | SOLE |
| 254604101 | IRON | Disc Medicine Inc | $78.5M | 2.34% | 988,401 | Common | SOLE |
| 86366E106 | GPCR | Structure Therapeutics Inc | $75.0M | 2.24% | 1,078,698 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $72.3M | 2.16% | 8,165,374 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $71.7M | 2.14% | 3,007,077 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $71.3M | 2.13% | 2,247,347 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $70.2M | 2.09% | 1,507,636 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics Inc | $68.5M | 2.04% | 3,502,941 | Common | SOLE |
| 03753U106 | APLSUSD | Apellis Pharmaceuticals Inc | $64.8M | 1.93% | 2,578,396 | Common | SOLE |
| 19240Q201 | COGT | Cogent Biosciences Inc | $57.9M | 1.73% | 1,629,279 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $55.8M | 1.66% | 2,000,000 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $55.7M | 1.66% | 10,129,913 | Common | SOLE |
| 76243J105 | RYTM | Rhythm Pharmaceuticals Inc | $53.5M | 1.60% | 499,975 | Common | SOLE |
| 04351P101 | ASNDUSD | Ascendis Pharma A/S | $50.3M | 1.50% | 235,862 | Common | SOLE |
| 75382E208 | RAPT | RAPT Therapeutics Inc | $46.6M | 1.39% | 1,375,000 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $46.0M | 1.37% | 9,969,495 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $44.8M | 1.34% | 38,918,903 | Common | SOLE |
| 98985Y108 | ZYME | Zymeworks Inc | $44.2M | 1.32% | 1,680,121 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $43.4M | 1.29% | 7,690,405 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $41.6M | 1.24% | 2,450,000 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $36.4M | 1.09% | 812,761 | Common | SOLE |
| 23306J309 | DBVT | Dbv Technologies SA | $35.6M | 1.06% | 1,857,362 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $32.6M | 0.97% | 8,757,249 | Common | SOLE |
| 29286M105 | — | enGene Holdings Inc | $30.1M | 0.90% | 3,336,264 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $28.6M | 0.85% | 2,286,867 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $26.8M | 0.80% | 818,598 | Common | SOLE |
| 603170101 | MLYS | Mineralys Therapeutics Inc | $25.4M | 0.76% | 699,999 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $23.1M | 0.69% | 1,396,513 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $22.3M | 0.67% | 1,618,271 | Common | SOLE |
| 359616109 | FULC | Fulcrum Therapeutics Inc | $22.1M | 0.66% | 1,950,000 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $21.5M | 0.64% | 708,469 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $17.7M | 0.53% | 2,911,438 | Common | SOLE |
| G4701H109 | IHS | IHS Holding Limited | $17.6M | 0.52% | 2,357,520 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $16.1M | 0.48% | 5,208,968 | Common | SOLE |
| 91678A107 | UPB | Upstream Bio Inc | $16.0M | 0.48% | 588,450 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $14.3M | 0.43% | 2,012,752 | Common | SOLE |
| 61023L207 | MNPR | Monopar Therapeutics Inc | $13.9M | 0.41% | 212,298 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $12.4M | 0.37% | 1,193,410 | Common | SOLE |
| 829401108 | SION | Sionna Therapeutics Inc | $12.3M | 0.37% | 300,000 | Common | SOLE |
| 45719W205 | IKT | Inhibikase Therapeutics Inc | $12.0M | 0.36% | 5,850,000 | Common | SOLE |
| 44975P103 | NBP | NovaBridge Biosciences | $11.9M | 0.36% | 3,000,000 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $11.9M | 0.35% | 51,500 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $11.3M | 0.34% | 6,288,783 | Common | SOLE |
| 60255C885 | BRD1EUR | Mind Medicine (MindMed) Inc | $10.7M | 0.32% | 800,000 | Common | SOLE |
| 08205P209 | BNTC | Benitec Biopharma Inc | $10.4M | 0.31% | 775,000 | Common | SOLE |
| 00534A102 | IVVD | Invivyd Inc | $9.9M | 0.29% | 4,000,000 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $8.4M | 0.25% | 27,700 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $8.2M | 0.25% | 1,007,575 | Common | SOLE |
| 56565P103 | MPLT | MapLight Therapeutics Inc | $7.9M | 0.24% | 450,000 | Common | SOLE |
| 697947109 | PVLA | Palvella Therapeutics Inc | $7.9M | 0.23% | 75,000 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $7.7M | 0.23% | 16,500 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $7.6M | 0.23% | 170,000 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $7.3M | 0.22% | 4,000,000 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $7.3M | 0.22% | 15,000 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $7.2M | 0.21% | 63,401 | Common | SOLE |
| 52886X107 | LXEO | Lexeo Therapeutics Inc | $7.2M | 0.21% | 720,622 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $7.0M | 0.21% | 37,485 | Common | SOLE |
| 79466L302 | CRM | Salesforce Inc | $6.9M | 0.21% | 26,100 | Common | SOLE |
| 20451W101 | CMPS | Compass Pathways PLC | $6.9M | 0.21% | 1,000,000 | Common | SOLE |
| 090168105 | BLLN | BillionToOne Inc | $6.9M | 0.20% | 83,833 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $6.8M | 0.20% | 79,123 | Common | SOLE |
| G9TY5A101 | ZURA | Zura Bio Ltd | $6.8M | 0.20% | 1,300,000 | Common | SOLE |
| 918385204 | VTVT | vTv Therapeutics Inc | $6.5M | 0.19% | 163,000 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $6.5M | 0.19% | 20,703 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $6.4M | 0.19% | 76,218 | Common | SOLE |
| 805111101 | SVRA | Savara Inc | $6.0M | 0.18% | 1,000,000 | Common | SOLE |
| 98420X202 | XFOR | X4 Pharmaceuticals Inc | $6.0M | 0.18% | 1,500,000 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $5.8M | 0.17% | 93,616 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $5.5M | 0.16% | 35,630 | Common | SOLE |
| 88032L605 | TENX | Tenax Therapeutics Inc | $5.2M | 0.16% | 427,141 | Common | SOLE |
| 00032Q104 | WHWK | Whitehawk Therapeutics Inc | $5.0M | 0.15% | 2,082,000 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $5.0M | 0.15% | 115,229 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $5.0M | 0.15% | 36,425 | Common | SOLE |
| 022307102 | ALMS | Alumis Inc | $4.9M | 0.15% | 500,000 | Common | SOLE |
| 30303M102 | META | Meta Platforms Inc | $4.7M | 0.14% | 7,169 | Common | SOLE |
| 713317105 | PEPG | PepGen Inc | $4.6M | 0.14% | 700,000 | Common | SOLE |
| 786700104 | SGMT | Sagimet Biosciences Inc | $4.3M | 0.13% | 724,771 | Common | SOLE |
| 00724F101 | ADBE | Adobe Inc | $4.2M | 0.13% | 12,051 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc | $3.9M | 0.12% | 720,720 | Common | SOLE |
| 37637K108 | GTLB | GitLab Inc | $3.7M | 0.11% | 99,000 | Common | SOLE |
| 482929106 | KLRS | Kalaris Therapeutics Inc | $3.7M | 0.11% | 435,798 | Common | SOLE |
| 647581206 | EDU | New Oriental Education & Technology Group Inc | $3.4M | 0.10% | 62,000 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $3.3M | 0.10% | 1,064,250 | Common | SOLE |
| 58507V107 | MDLN | Medline Inc | $3.1M | 0.09% | 75,000 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $2.8M | 0.08% | 347,718 | Common | SOLE |
| M2197Q107 | CLBT | Cellebrite DI Ltd | $2.7M | 0.08% | 150,000 | Common | SOLE |
| 753018100 | RANI | Rani Therapeutics Holdings Inc | $2.7M | 0.08% | 2,000,000 | Common | SOLE |
| 98980G102 | ZS | Zscaler Inc | $2.7M | 0.08% | 12,000 | Common | SOLE |
| 09203E105 | BDTX | Black Diamond Therapeutics Inc | $2.5M | 0.08% | 1,046,517 | Common | SOLE |
| M7S64H106 | MNDY | monday.com Ltd | $2.5M | 0.07% | 17,000 | Common | SOLE |
| 11135F101 | AVGO | Broadcom Inc | $2.4M | 0.07% | 7,000 | Common | SOLE |
| 747525103 | QCOM | Qualcomm Inc | $2.4M | 0.07% | 14,000 | Common | SOLE |
| 042068205 | ARM | Arm Holdings PLC | $2.4M | 0.07% | 21,500 | Common | SOLE |
| 482497104 | BEKE | Ke Holdings Inc | $2.3M | 0.07% | 145,000 | Common | SOLE |
| 45783C200 | TIL | Instil Bio Inc | $2.2M | 0.07% | 203,933 | Common | SOLE |
| 697435105 | PANW | Palo Alto Networks Inc | $2.1M | 0.06% | 11,450 | Common | SOLE |
| 21873S108 | CRWV | CoreWeave Inc | $2.0M | 0.06% | 27,500 | Common | SOLE |
| Q4982L109 | IREN | IREN Ltd | $1.6M | 0.05% | 43,100 | Common | SOLE |
| 922280102 | VRNS | Varonis Systems Inc | $1.2M | 0.04% | 37,500 | Common | SOLE |
| 741623102 | PRMB | Primo Brands Corp | $1.2M | 0.04% | 75,000 | Common | SOLE |
| 37148K209 | — | Generation Bio Inc | $1.1M | 0.03% | 201,419 | Common | SOLE |
| 316841105 | FIG | Figma Inc | $934,250 | 0.03% | 25,000 | Common | SOLE |
| 88160R101 | TSLA | Tesla Inc | $674,580 | 0.02% | 1,500 | Common | SOLE |
| 142038108 | CRBU | Caribou Biosciences Inc | $167,502 | 0.00% | 105,347 | Common | SOLE |
| 23255M204 | CYCN | Cyclerion Therapeutics Inc | $146,816 | 0.00% | 115,603 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.