Q1 2026 · 13F-HR
Siren, L.L.C.holdings as filed
Filed 2026-05-14 · accession 0002005245-26-000006
$3.61B
Reported value
100
Positions
2026-03-31
Period end
The Brief · Siren, L.L.C. · Q1 2026
AI · grounded in 13F
Siren, L.L.C. closed its position in APLSUSD for a reduction of $64.77M. The fund established new positions in MANE for $95.06M and CYTK for $40.47M. Additionally, the fund increased its holdings in ORIC by 197.57% and XENE by 62.23%.
Holdings as filed
| CUSIP | Ticker | Issuer | Value | % port. | Shares | Class | Voting |
|---|---|---|---|---|---|---|---|
| 80706P103 | SRRK | Scholar Rock Holding Corp | $532.2M | 14.8% | 10,825,013 | Common | SOLE |
| 501575104 | KYMR | Kymera Therapeutics Inc | $265.4M | 7.36% | 3,186,830 | Common | SOLE |
| 29479A108 | ERAS | Erasca Inc | $181.9M | 5.04% | 11,244,246 | Common | SOLE |
| 28036F105 | EWTX | Edgewise Therapeutics Inc | $139.6M | 3.87% | 4,430,263 | Common | SOLE |
| 07725L102 | ONC | BeOne Medicines AG | $138.1M | 3.83% | 465,000 | Common | SOLE |
| 87583X109 | TNGX | Tango Therapeutics Inc | $118.3M | 3.28% | 5,657,105 | Common | SOLE |
| 055477103 | BCAX | Bicara Therapeutics Inc | $115.4M | 3.20% | 5,802,970 | Common | SOLE |
| 76155X100 | RVMD | Revolution Medicines Inc | $108.0M | 3.00% | 1,110,980 | Common | SOLE |
| 04280A100 | ARWR | Arrowhead Pharmaceuticals Inc | $101.3M | 2.81% | 1,615,476 | Common | SOLE |
| 922967104 | MANE | Veradermics Inc | $95.1M | 2.64% | 1,505,374 | Common | SOLE |
| 98420N105 | XENE | Xenon Pharmaceuticals Inc | $76.7M | 2.13% | 1,318,564 | Common | SOLE |
| 68062P106 | OLMA | Olema Pharmaceuticals Inc | $70.9M | 1.97% | 4,756,949 | Common | SOLE |
| 22663K107 | CRNX | Crinetics Pharmaceuticals Inc | $69.1M | 1.92% | 1,903,636 | Common | SOLE |
| 528872302 | LXRX | Lexicon Pharmaceuticals Inc | $69.1M | 1.92% | 44,303,518 | Common | SOLE |
| 19240Q201 | COGT | Cogent Biosciences Inc | $65.8M | 1.82% | 1,709,279 | Common | SOLE |
| 86150R107 | STOK | Stoke Therapeutics Inc | $65.0M | 1.80% | 1,995,347 | Common | SOLE |
| 03969F109 | RCUS | Arcus Biosciences Inc | $65.0M | 1.80% | 3,007,077 | Common | SOLE |
| 86366E106 | GPCR | Structure Therapeutics Inc | $64.0M | 1.78% | 1,328,698 | Common | SOLE |
| 254604101 | IRON | Disc Medicine Inc | $63.2M | 1.75% | 988,401 | Common | SOLE |
| 76243J105 | RYTM | Rhythm Pharmaceuticals Inc | $63.1M | 1.75% | 725,511 | Common | SOLE |
| 83422E204 | SLDB | Solid Biosciences Inc | $55.4M | 1.53% | 7,690,405 | Common | SOLE |
| 81734D104 | SEPN | Septerna Inc | $48.1M | 1.33% | 2,000,000 | Common | SOLE |
| 152309100 | CNTA | Centessa Pharmaceuticals PLC | $41.8M | 1.16% | 1,053,464 | Common | SOLE |
| 00773J202 | SYRE | Spyre Therapeutics Inc | $41.3M | 1.14% | 818,598 | Common | SOLE |
| 23282W605 | CYTK | Cytokinetics Inc | $40.5M | 1.12% | 613,952 | Common | SOLE |
| 26818M108 | DYN | Dyne Therapeutics, Inc | $40.4M | 1.12% | 2,229,125 | Common | SOLE |
| 877619106 | TSHA | Taysha Gene Therapies Inc | $39.5M | 1.09% | 8,829,913 | Common | SOLE |
| 23306J309 | DBVT | Dbv Technologies SA | $38.8M | 1.08% | 1,857,362 | Common | SOLE |
| 68622P109 | ORIC | Oric Pharmaceuticals Inc | $38.0M | 1.05% | 2,998,192 | Common | SOLE |
| 29286M105 | — | enGene Holdings Inc | $35.8M | 0.99% | 5,253,159 | Common | SOLE |
| 697947109 | PVLA | Palvella Therapeutics Inc | $32.1M | 0.89% | 257,485 | Common | SOLE |
| M8744T106 | TBLA | Taboola.com Ltd | $30.9M | 0.86% | 9,969,495 | Common | SOLE |
| 29337E102 | ELVN | Enliven Therapeutics Inc | $29.3M | 0.81% | 746,226 | Common | SOLE |
| 24823R105 | DNLI | Denali Therapeutics Inc | $26.8M | 0.74% | 1,396,513 | Common | SOLE |
| 75960P104 | RELY | Remitly Global Inc | $24.2M | 0.67% | 1,543,271 | Common | SOLE |
| 36322Q206 | DMRA | Damora Therapeutics Inc | $23.3M | 0.65% | 900,000 | Common | SOLE |
| G9TY5A101 | ZURA | Zura Bio Ltd | $22.2M | 0.62% | 3,734,866 | Common | SOLE |
| 03589W102 | ANNX | Annexon Inc | $21.9M | 0.61% | 3,958,646 | Common | SOLE |
| 89532M101 | TRVI | Trevi Therapeutics Inc | $21.3M | 0.59% | 1,786,867 | Common | SOLE |
| 75383L102 | RAPP | Rapport Therapeutics Inc | $20.1M | 0.56% | 641,469 | Common | SOLE |
| 02079K305 | GOOGL | Alphabet Inc | $18.9M | 0.52% | 65,703 | Common | SOLE |
| 359616109 | FULC | Fulcrum Therapeutics Inc | $18.0M | 0.50% | 2,350,000 | Common | SOLE |
| Y95308105 | WVE | WAVE Life Sciences Ltd | $17.8M | 0.49% | 2,450,000 | Common | SOLE |
| 24477V105 | DFTX | Definium Therapeutics Inc | $17.4M | 0.48% | 919,493 | Common | SOLE |
| 03237H101 | AMLX | Amylyx Pharmaceuticals Inc | $17.1M | 0.47% | 1,230,000 | Common | SOLE |
| 230031106 | CGEM | Cullinan Therapeutics Inc | $17.0M | 0.47% | 1,193,410 | Common | SOLE |
| 640979100 | NMRA | Neumora Therapeutics Inc | $16.6M | 0.46% | 8,497,822 | Common | SOLE |
| N90064101 | QURE | Uniqure NV | $16.4M | 0.45% | 1,000,000 | Common | SOLE |
| 23284F105 | CTMX | CytomX Therapeutics Inc | $16.3M | 0.45% | 3,457,711 | Common | SOLE |
| 67066G104 | NVDA | NVIDIA Corp | $15.5M | 0.43% | 89,085 | Common | SOLE |
| 82686Q101 | SLN | Silence Therapeutics PLC | $15.3M | 0.43% | 2,911,438 | Common | SOLE |
| 594918104 | MSFT | Microsoft Corp | $15.3M | 0.42% | 41,380 | Common | SOLE |
| 61023L207 | MNPR | Monopar Therapeutics Inc | $14.8M | 0.41% | 270,118 | Common | SOLE |
| 874039100 | TSM | Taiwan Semiconductor Manufacturing Co Ltd | $14.3M | 0.40% | 42,200 | Common | SOLE |
| 829401108 | SION | Sionna Therapeutics Inc | $12.0M | 0.33% | 300,000 | Common | SOLE |
| N97284108 | NBIS | Nebius Group NV | $11.8M | 0.33% | 113,614 | Common | SOLE |
| 76200L309 | RZLT | Rezolute Inc | $10.2M | 0.28% | 3,328,287 | Common | SOLE |
| 45719W205 | IKT | Inhibikase Therapeutics Inc | $9.8M | 0.27% | 5,850,000 | Common | SOLE |
| 023135106 | AMZN | Amazon.com Inc | $9.7M | 0.27% | 46,641 | Common | SOLE |
| 370920100 | GENB | Generate Biomedicines Inc | $9.2M | 0.26% | 736,104 | Common | SOLE |
| 56565P103 | MPLT | MapLight Therapeutics Inc | $9.1M | 0.25% | 450,000 | Common | SOLE |
| 81762P102 | NOW | ServiceNow Inc | $9.1M | 0.25% | 87,090 | Common | SOLE |
| 22788C105 | CRWD | CrowdStrike Holdings Inc | $9.0M | 0.25% | 23,070 | Common | SOLE |
| 722304102 | PDD | PDD Holdings Inc | $8.5M | 0.24% | 83,401 | Common | SOLE |
| 88160R101 | TSLA | Tesla Inc | $8.0M | 0.22% | 21,500 | Common | SOLE |
| 44975P103 | NBP | NovaBridge Biosciences | $7.4M | 0.20% | 3,000,000 | Common | SOLE |
| 088786108 | BCYC | Bicycle Therapeutics PLC | $7.2M | 0.20% | 1,560,882 | Common | SOLE |
| 00032Q104 | WHWK | Whitehawk Therapeutics Inc | $7.2M | 0.20% | 2,082,000 | Common | SOLE |
| 88032L605 | TENX | Tenax Therapeutics Inc | $6.8M | 0.19% | 427,141 | Common | SOLE |
| 918385204 | VTVT | vTv Therapeutics Inc | $6.5M | 0.18% | 163,000 | Common | SOLE |
| 23804L103 | DDOG | Datadog Inc | $6.4M | 0.18% | 54,300 | Common | SOLE |
| M6191J100 | FROG | Jfrog Ltd | $6.0M | 0.17% | 128,816 | Common | SOLE |
| 268150109 | DT | Dynatrace Inc | $5.5M | 0.15% | 150,000 | Common | SOLE |
| 98139A105 | WK | Workiva Inc | $5.5M | 0.15% | 92,500 | Common | SOLE |
| 00091E109 | ABSI | Absci Corp | $5.4M | 0.15% | 1,800,000 | Common | SOLE |
| 00534A102 | IVVD | Invivyd Inc | $5.2M | 0.14% | 4,000,000 | Common | SOLE |
| 80401L803 | MSLE | Satellos Bioscience Inc | $5.0M | 0.14% | 892,074 | Common | SOLE |
| 46222L108 | IONQ | IONQ Inc | $4.9M | 0.14% | 170,000 | Common | SOLE |
| 11135F101 | AVGO | Broadcom Inc | $4.6M | 0.13% | 15,000 | Common | SOLE |
| 00860C102 | AGMB | Agomab Therapeutics NV | $4.3M | 0.12% | 411,250 | Common | SOLE |
| M2197Q107 | CLBT | Cellebrite DI Ltd | $4.3M | 0.12% | 311,544 | Common | SOLE |
| 81578P106 | SEER | Seer Inc | $4.1M | 0.11% | 2,458,673 | Common | SOLE |
| 500946108 | KRRO | Korro Bio Inc | $3.9M | 0.11% | 347,718 | Common | SOLE |
| 00847G804 | AGEN | Agenus Inc | $3.6M | 0.10% | 1,064,250 | Common | SOLE |
| 344174107 | FHTX | Foghorn Therapeutics Inc | $3.4M | 0.10% | 720,720 | Common | SOLE |
| 34631F102 | FPS | Forgent Power Solutions, Inc | $2.9M | 0.08% | 100,000 | Common | SOLE |
| 482929106 | KLRS | Kalaris Therapeutics Inc | $2.5M | 0.07% | 435,798 | Common | SOLE |
| 37637K108 | GTLB | GitLab Inc | $2.2M | 0.06% | 100,000 | Common | SOLE |
| 595112103 | MU | Micron Technology Inc | $2.0M | 0.06% | 6,000 | Common | SOLE |
| M7S64H106 | MNDY | monday.com Ltd | $1.7M | 0.05% | 25,000 | Common | SOLE |
| 38341P102 | GOSS | Gossamer Bio Inc | $1.7M | 0.05% | 5,208,968 | Common | SOLE |
| G0260P102 | AS | Amer Sports Inc | $1.6M | 0.05% | 50,000 | Common | SOLE |
| 482497104 | BEKE | KE Holdings Inc | $1.5M | 0.04% | 100,000 | Common | SOLE |
| Q4982L109 | IREN | IREN Ltd | $1.5M | 0.04% | 43,100 | Common | SOLE |
| 753018100 | RANI | Rani Therapeutics Holdings Inc | $1.5M | 0.04% | 2,000,000 | Common | SOLE |
| 00835Q202 | AEVA | Aeva Technologies Inc | $1.4M | 0.04% | 110,000 | Common | SOLE |
| 58507V107 | MDLN | Medline Inc | $1.1M | 0.03% | 25,000 | Common | SOLE |
| 316841105 | FIG | Figma Inc | $1.1M | 0.03% | 50,000 | Common | SOLE |
| 741623102 | PRMB | Primo Brands Corp | $941,500 | 0.03% | 50,000 | Common | SOLE |
| G6683N103 | NU | Nu Holdings Ltd. | $359,250 | 0.01% | 25,000 | Common | SOLE |
Source: SEC EDGAR · raw 13F holdings as filed. The Class column shows the option type when reported (Put/Call) or Common when the issuer's equity is held directly. 13F discloses long positions only.